CAS 4584-46-7 MFCD00012516-2-Chloro-N,N-dimethylethanamine hydrochloride (第二类监控化学品，不能销售)二甲氨基氯乙烷盐酸 TAO{mole}

2-Chloro-N,N-dimethylethanamine hydrochloride (第二类监控化学品，不能销售)二甲氨基氯乙烷盐酸

CAS 4584-46-7 MFCD00012516

化学结构图

SMILES: CN(C)CCCl.Cl

化学属性

Mol. Formula	C₄H₁₁Cl₂N
Mol. Weight	144.04
Melting Point	203-206°C (dec.)
TSCA	Yes
Solubility	Soluble in water (2000 mg/ml at 20 °C), and alcohol.
Stability	易吸潮

别名和识别编码

Chemical Name	2-Chloro-N,N-dimethylethanamine hydrochloride
CAS Number	4584-46-7
Alfabeta Name	CHLOROETHYLDIMETHYLAMINEHYDROCHLORIDE 2-
MDL Number	MFCD00012516
Synonym	(2-Chloroethyl)dimethylamine, h (Β-氯乙基)二甲胺盐酸盐 (β-Chloroethyl)dimethylamine hydrochloride (β-氯乙基)二甲胺,盐酸盐 1-(di 1-CHLORO-2-DIMETHYLAMINOETHANE HYDROCHLORID 1-Chloro-2-(dimethylamino)ethane hydrochloride 1-Chloro-2-N, 1-N,N-dimethylamino-2-chloroethane hydrochloride 1-氯-2-二甲基氨基乙烷盐酸盐 2-(二甲基氨基)乙基氯盐酸盐 N-(2-氯乙基)二甲胺盐酸盐 2- 2-(DIMETHYLAMINO)ETHYL CHLORIDE HCL 2-(Dimethylamino)ethyl chloride hydrochloride 2-(二甲基氨)乙基氯盐酸盐, 98+% 2-(二甲氨基)乙基氯盐酸盐 2-CHLORO-N,N-DIMETHYLETHYLAMINE HYDROCHLORID 2-Chlor-N,N-dimethyl-1-ethanamin Hydrochlordid 2-Chloro-N,N-dimethylethanamine hydrochlo 2-Chloro-N,N-dimethylethylamine Hydrochloride {} {} {} {} {} {} { {} {} {} {} {} {} {uni_hamburg} 2
PubChem Substance ID	11636816
EC Number	224-970-1
Beilstein Registry Number	3591234
Chemical Name Translation	(第二类监控化学品，不能销售)二甲氨基氯乙烷盐酸
Wiswesser Line Notation	G2N1&1 &GH
InChI	InChI=1S/C4H10ClN.ClH/c1-6(2)4-3-5;/h3-4H2,1-2H3;1H

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产品应用

医药中间体。用于生产抗组胺药盐酸派力本沙明。

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany3

Hazard statements

H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T+;N T T,N,T+

RTECSKQ9020000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P312
P301+P316
P301+P317
P302+P352
P304+P340
P305+P351+P338
P308+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P318
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

UN Number UN 2811 6.1/PG 3 2811 UN2811

Risk Statements

R24 Toxic in contact with skin 与皮肤接触有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R51/53
R26 Very toxic by inhalation 吸入极毒

Storage condition 4°C, Hygroscopic Hygroscopic 易吸潮，密封保存

Packing GroupIII

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 720 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,391,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Gastrointestinal - other changes
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 2,1055,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Blood - hemorrhage
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539178

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 97,25,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 238 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Sci

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1700 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 95,237,1982

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,81,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 umol/L
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 31,67P,1979

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 5 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,33,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,33,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southf

其他信息

外观性质:有吸湿性。溶于水(20℃,2000g/L)和乙醇。有毒。有刺激性熔点:205-208℃
Alfa Aesar:2-二甲基氨乙基氯盐酸盐,98+% 2-Dimethylaminoethyl chloride hydrochloride, 98+%(4584-46-7)
MOL 文件:4584-46-7.mol
二甲氨基氯乙烷盐酸价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 115825000 二甲氨基氯乙烷盐酸 2-Dimethylaminoethyl chloride hydrochloride 99% 500 GR 506元 2010/06/21 115820025 二甲氨基氯乙烷盐酸 2-Dimethylaminoethyl chloride hydrochloride 99% 2.5 KG 1999元 2010/06/21 115821000 二甲氨基氯乙烷盐酸 2-Dimethylaminoethyl chloride hydrochloride 99% 100 GR 173元
MSDS 信息:2-chloroethyldimethylammonium chloride(4584-46-7).msds
用途一:用于生产硅油、硅橡胶等
Acros Organics:2-(二甲氨基)乙基氯盐酸盐 2-Dimethylaminoethyl chloride hydrochloride, 99%(4584-46-7)
用途三:医药中间体。用于生产抗组胺药盐酸派力本沙明。
方法一:由二甲胺经与氯乙酐缩合、氯化亚砜氯化而得。
上游原料:氧氯化硫 --> N,N-二甲基乙醇胺 --> 氯乙酸酐
海关编码:29211980
用途二:用作有机合成、医药中间体
敏感性:Hygroscopic
Sigma Aldrich:4584-46-7(sigmaaldrich)
图谱信息:二甲氨基氯乙烷盐酸(4584-46-7)质谱(MS) 二甲氨基氯乙烷盐酸(4584-46-7)红外图谱(IR1) 二甲氨基氯乙烷盐酸(4584-46-7)Raman光谱二甲氨基氯乙烷盐酸(4584-46-7)核磁图( 1 HNMR) 二甲氨基氯乙烷盐酸(4584-46-7)红外图谱(IR2) 二甲氨基氯乙烷盐酸(4584-46-7)核磁图( 13 CNMR)
有吸湿性。溶于水(20℃,2000g/L)和乙醇。有毒。有刺激性
下游产品:2-氯-6-甲基苯甲醛,98% --> 1-(2-二甲基氨基乙基)哌嗪 --> 4-[2-(二甲胺基)乙氧基]苯甲醛 --> N'-苯甲基-N,N-二甲基乙二胺