Pazopanib 帕唑帕尼

CAS 444731-52-6 MFCD11616589

化学结构图

444731-52-6
SMILES: Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O

化学属性

Mol. FormulaC21H23N7O2S
Mol. Weight438
Density1.3
Boiling Point658
Melting Point301-313
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NamePazopanib
CAS Number444731-52-6
Alfabeta NameDIMETHYLINDAZOLYLMETHYLAMINOPYRIMIDINYLAMINOMETHYLBENZENESULFONAMIDE H54232622[[]]()---------------,
MDL NumberN/A
Synonym GW-786034, 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide GW786034; GW786034; GW 786034; Pazopanib; US brand name: Votrient.
Chemical Name Translation帕唑帕尼
FormulaC21H23N7O2S
IUPAC Name5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
InChIKeyCUIHSIWYWATEQL-UHFFFAOYSA-N
InChIInChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
Canonical SMILESO=S(C1=CC(NC2=NC=CC(N(C3=CC4=NN(C)C(C)=C4C=C3)C)=N2)=CC=C1C)(N)=O
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Pazopanib is an approved drug, is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

相关文献及参考

  • Olaussen, K., et al.: Oncogen., 28, 4249 (2009),
  • Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009),
  • Chan, A., et al.: Drugs, 69, 167 (2009),

安全信息

Warnings IRRITANT
GHS Symbol
Signal word Warning
Safety Statements
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R62/63
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P308+P313
  • P333+P313
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. PDGFR
  1. Medical Research Areas
  2. Protein Tyrosine Kinase
  3. c-Kit

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