Fluorometholone 氟米龙
CAS 426-13-1 MFCD00056461
化学结构图
SMILES: CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
化学属性
| Mol. Formula | C22H29FO4 |
|---|---|
| Mol. Weight | 376.47 |
| Density | 1.422 |
| Refractive index | 55 ° (C=1, Pyridine) |
别名和识别编码
| Chemical Name | Fluorometholone |
|---|---|
| CAS Number | 426-13-1 |
| Synonym | fluoromethalone oxylone 11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione 氟米龙 Cortilet {Chemi 11-BETA,17-ALPHA-DIHYDROXY-9-FLUORO-6-METHYL-4-ANDROSTEN-3-ONE 11β,17α-dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6α, 11β)- cortilet Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-6α-methyl- Delmeson Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6α,11β)- 9a-Fluoro-11ß,17a-dihydroxy-6a-m Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6a, 11ß)- ######## 6a-Methyl-9a-fluoro-11ß,17a-dihydroxypregna-1,4-diene-3,20-dione {Ch 1,4-PREGNADIEN-9-ALPHA-FLUORO-6-ALPHA-METHYL-11-BETA, 17-DIOL-3,20-DIONE 9α-Fluoro-11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione {uni_hambu 11BETA,17ALPHA-DIHYDROXY-9-FLUORO-6-METHYL-1,4-PREGNADIENE-3 6α-Methyl-9α- Trilcin Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11ß)- 20-dione,9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl-pregna-4-diene-3 9a-fluoro-11b,17a-dihydroxy-6a-methyl-1,4-pregnadiene-3,20-dione pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-,(6-alpha,11-be Progesterone, 1-dehydro-9-fluoro-11ß, 17-dihydroxy-6a-methyl- {hazar 9a-Fluoro-11b,17a-dihydroxy-6a-methyl-1,4-pregnadiene-3,20-dione; 11b,17a-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-di U 8614 11b,17a-dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione 6a-Methyl-9a-fluoro-21-desoxypred |
| MDL Number | MFCD00056461 |
| PubChem Substance ID | 9878 |
| EC Number | 207-041-5 |
| Reaxys-RN | 3172388 |
| Merck Number | 4175 |
| Beilstein Registry Number | 2384789 |
| Chemical Name Translation | 氟米龙 |
| LabNetwork Molecule ID | LN01299210 |
| InChI | InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 |
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分类
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards,
- {SNA} Cytokines, Growth Factors and Hormones, Hormones, Other Steroid Products, Steroid Hormones, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards E - F
- {SNA} Analyti
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, F, Hormones, Other Steroid Products, Steroid Hormones
产品应用
- Fluorometholone is a glucocorticoid; anti-inflammatory.
相关文献及参考
- 1. Tabbara, K.F. and al-Kharashi S.A., Efficacy of nedocromil 2% versus fluorometholone 0.1%: a randomised, double masked trial comparing the effects on severe vernal keratoconjunctivitis Br. J. Ophthalmol. 83 , 180-184, (1999)
- Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982),
- Merck 14 ,4175
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: htt
- Short: II/27C Title: Diamagnetic Susceptibility and Magnetic Anisotropy of Organic Compounds Author: Kumar, Mahendra; Gupta, Rajni Editor: Gupta, Radha Raman Source: Landolt-Börnstein, New Series Volume: II/27C Year: 2008 Keyword: diamagnetic susceptibility; magnetic anisotropy; organic compounds ISBN: 978-3-540-44734-4 (print) ISBN: 978-3-540-44736-8 (online) Internet Resource: doi:10.1007/978-3-540-44736-8 RefComment: VIII,
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P304+P340+P312
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P305+P351+P338
- P302+P352+P312+P362+P364
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H302+H312+H332
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 443 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,981,1990
其他信息
- TCI Shanghai:氟米龙 Fluorometholone,>;98.0%(LC)(426-13-1)
- MOL 文件:426-13-1.mol
- 氟米龙价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 F0414 氟米龙 Fluorometholone 1G 2700元
- 氟米龙价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0414 氟米龙 Fluorometholone 1G 3430元
- MSDS 信息:11b,17a-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione(426-13-1).msds
- Sigma Aldrich:426-13-1(sigmaaldrich)
