Acivicin 阿西维辛
CAS 42228-92-2 MFCD00058450
化学结构图
SMILES: NC(C1CC(Cl)=NO1)C(O)=O
化学属性
| Mol. Formula | C5H7ClN2O3 |
|---|---|
| Mol. Weight | 178.59 |
别名和识别编码
| Chemical Name | Acivicin |
|---|---|
| CAS Number | 42228-92-2 |
| Synonym | (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid Antibiotic AT 125 α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic acid NSC 163501 U 42126 AT 125 Acivicine (a-S, 5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid NSC-163501 (?S,5S)- |
| MDL Number | MFCD00058450 |
| Chemical Name Translation | 阿西维辛 |
| Beilstein Registry Number | 1074648 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Detection and Quantitation, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents, Reagents
- {SNA} A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids
产品应用
- Azaserine and Acivicin are classical and irreversible inhibitors of ?-Glutamyltranspeptidase
相关文献及参考
- Hanigan, M., et al.: Biochemistry, 32, 6302 (1993),
- Vermeulin, M.A., et al., Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity. World J. Gastroenterol. 17 , 1569-1573, (2011)
- Hilgier, W., et al., Direct exposure to ammonia and hyperammonemia increase the extracellular accumulation and degradation of astroglia-derived glutathione in the rat prefrontal cortex. Toxicol. Sci. 117 , 163-168, (2010)
- Circu, M.L., et al., The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells. Biochem. Pharmacol. 77 , 76-85, (2009)
安全信息
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 250 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,129,1989
TYPE OF TEST : DNA inhibition TEST SYSTEM : Bird - chicken Embryo DOSE/DURATION : 6 umol/L REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,633,1983
