1H-[1,2,4]Oxadiazolo[4,3-A]Quinoxalin-1-One 1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮
CAS 41443-28-1 MFCD00792620
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Inhibitors,
- {SNA} Cyclic Nucleotide Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Inhibitors, Guanylyl cyclase, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
产品应用
- 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.
相关文献及参考
- Lee, H.G., et al.: J. Neurosci. Res., 87 269 (2009),
- Schrammel, et al., Characterization of 1H [1,2,4]oxadiazolo[4,3a]quinoxalin1one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol. Pharmacol. 50 , 1-5, (1996) 摘要
- Brunner, et al., Novel guanylyl cyclase inhibitor ODQ reveals role of nitric oxidebut not of cyclic-GMP in endothelin-1 secretion. FEBS Lett. 376 , 262-266, (1995) 摘要
- Garthwaite, et al., Potent and selective inhibition of nitric oxidesensitive guanylyl cyclase by 1H[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one. Mol. Pharmacol. 48 , 184-188, (1995) 摘要
- Vielma, A., et al., Nitric Oxide Amplifies The Rat Electroretinogram. Exp. Eye Res. 91 , 700-9, (2010) 摘要
安全信息
GHS Symbol

- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性