CAS 404-82-0 MFCD00058016-Phenethylamine,N-ethyl-alpha-methyl-m-(trifluoromethyl)-,hydrochloride 盐酸芬氟拉明 TAO{mole}

Phenethylamine,N-ethyl-alpha-methyl-m-(trifluoromethyl)-,hydrochloride 盐酸芬氟拉明

CAS 404-82-0 MFCD00058016

化学结构图

SMILES: CCNC(C)Cc1cccc(C(F)(F)F)c1

化学属性

Mol. Formula	-
Mol. Weight	-
Appearance	白色结晶性粉末，无嗅
Melting Point	1660C

别名和识别编码

Chemical Name	Phenethylamine,N-ethyl-alpha-methyl-m-(trifluoromethyl)-,hydrochloride
Synonym	(±)-Fenfluramine hydrochloride (±)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride (+)-n-ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride (+/-)-FENFLURAMINE HYDROCHLORIDE 1-(3-Trifluoromethylphenyl)-2-ethylaminopropane hydrochloride 1-(3-trifluoromethylphenyl)-2-ethylaminopropanehydrochloride FEBFLURAMINE HYDROCHLORIDE FENFLURAMINE (UNLABELED) 1.0 MG/ML IN METHANOL FENFLURAMINE HCL FENFLURAMINE HYDROCHLORIDE FENFLURAMINE HYDROCHLORIDE MM(CRM STANDARD) Fenfluramine hydrochloride Fenfluramine hydrochloride 100 µg/mL in Acetonitrile {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00058016
PubChem Substance ID	91452
CAS Number	404-82-0
EC Number	206-968-2
Chemical Name Translation	盐酸芬氟拉明
Wiswesser Line Notation	FXFFR C1Y1&M2 &GH
InChI	InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

安全信息

RTECSSH6825000

WGK Germany3

GHS Symbol

Precautionary statements

P301+P310

Signal word Danger

Hazard statements

H301 Toxic if swallowed 吞食有毒

Hazard Codes T

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S22 Do not breathe dust 不要吸入粉尘；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Risk Statements

R25 Toxic if swallowed 吞咽有毒

Packing GroupIII

Hazard Class6.1(b)

Storage condition 2-8°C

UN Number UN 2811 6.1/PG 3

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   19,705,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   19,705,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,740,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperito

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1500 ug/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,323,1992

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1500 ug/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,323,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 280 mg/kg
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   205,1220,1979

其他信息

用途一:减肥药。适用于单纯性肥胖。3-4d后血药水平达到稳态，产生疗效。
Sigma Aldrich:404-82-0(sigmaaldrich)
下游产品:氟苯丙胺
MOL 文件:404-82-0.mol