PD0325901 MEK1/2抑制剂III

CAS 391210-10-9 MFCD08435926

化学结构图

391210-10-9
SMILES: O=C(NOC[C@H](O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F

化学属性

Mol. FormulaC16H14F3IN2O4
Mol. Weight482
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NamePD0325901
CAS Number391210-10-9
Alfabeta NameDIHYDROXYPROPOXYDIFLUOROFLUOROIODOPHENYLAMINOBENZAMIDE RN2334224((()))----------,,
MDL NumberN/A
Synonym (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]be PD 0325901 PD0325901; PD 0325901; PD-325901; mirdametinibum; mirdametinib
Chemical Name TranslationMEK1/2抑制剂III
PubChem Substance ID329823743
FormulaC16H14F3IN2O4
IUPAC Name(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
InChIKeySUDAHWBOROXANE-SECBINFHSA-N
InChIInChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
Canonical SMILESO=C(NOC[C@H](O)CO)C1=CC=C(F)C(F)=C1NC2=CC=C(I)C=C2F
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Pfizer Compounds
  • Chiral Reagents
  • Pharmaceuticals
  • Aromatics
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, P-PH, Pfizer Compounds, 生物活性小分子, 细胞生物学
  • Intermediates & Fine Chemicals,

产品应用

  • PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.

相关文献及参考

  • Davies, H., et al.: Nature, 417, 949 (2002),

安全信息

Warnings IRRITANT
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P301+P310
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H301 Toxic if swallowed 吞食有毒
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
WGK Germany3
Signal word Danger
Hazard Codes T,N
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Pfizer Compounds - Approved Therapeutics/Drug Candidates
  1. Medical Research Areas
  2. MARK
  3. MEK
  1. Medical Research Areas
  2. MARK
  3. Raf

相关产品推荐