艾菲地可宁, 来源于黑曲霉 艾菲地可宁, 来源于黑曲霉
CAS 38966-21-1 MFCD00083214
化学结构图
SMILES: C[C@]12CC[C@@H](O)[C@@](C)(CO)[C@@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO
化学属性
| Mol. Formula | C20H34O4 |
|---|---|
| Mol. Weight | 338 |
| Melting Point | 227-233 °C(lit.) |
别名和识别编码
| Chemical Name | Aphidicolin from Nigrospora sphaerica |
|---|---|
| Synonym | Aphidicolin ICI 69653 APC NSC-234714 |
| MDL Number | MFCD00083214 |
| PubChem Substance ID | 24890452 |
| Beilstein Registry Number | 4689958 |
| CAS Number | 38966-21-1 |
| Chemical Name Translation | 艾菲地可宁, 来源于黑曲霉 |
| Wiswesser Line Notation | L C6 B656 A 1B P BXTJ C1 FQ G1Q NQ N1Q |
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分类
- {SNA} AN-AZ, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Interferes with DNA Synthesis, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards,
相关文献及参考
- Spadari, S., et al., Control of cell division by aphidicolin without adverse effects upon resting cells. Arzneimittelforschung 35 , 1108-1116, (1985) 摘要
- Yamada, K., and Itoh, R., Involvement of DNA polymerase delta and/or epsilon in joining UV-induced DNA single strand breaks in human fibroblasts. Biochim. Biophys. Acta 1219 , 302-306, (1994) 摘要
- Cheng, C.H., and Kuchta, R.D., DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Biochemistry 32 , 8568-8574, (1993) 摘要
- Mutomba, M.C., and Wang, C.C., Effects of aphidicolin and hydroxyurea on the cell cycle and differentiation of Trypanosoma brucei bloodstream forms. Mol. Biochem. Parasitol. 80 , 89-102, (1996) 摘要
- Kuwakado, K., et al., Augmentation by aphidicolin of 1-β-D-arabinofuranosylcytosine-induced c-jun and NF-kappa B activation in a human myeloid leukemia cell line: correlation with apoptosis. Leuk. Res. 19 , 645, (1995) 摘要
- Wang, N.D., et al., Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. Genomics 17 , 341-347, (1993) 摘要
- McAllister, B.F., and Greenbaum, I.F., How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse ( Peromyscus maniculatus ). Hum. Genet. 100 , 182-188, (1997) 摘要
- Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME, Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J. Biol. Chem. , 9728-37, (2005)
- Isaac CE, et. al., The retinoblastoma protein regulates pericentric heterochromatin. Mol. Cell. Biol. , 3659-71, (2006) 摘要
- Rowe, J., et al., Compounds That Target Host Cell Proteins Prevent Varicella-zoster Virus Replication
安全信息
GHS Symbol
TYPE OF TEST : DNA inhibition
{hTYPE OF TEST : DNA inhibition TEST SYSTEM : Human Leukocyte DOSE/DURATION : 1 mg/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,1829,1991
TYPE OF TEST : DNA inhibition TEST SYSTEM : Mammal - species unspecified Fibroblast DOSE/DURATION : 1 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 160,103,1986
TYPE OF TEST : DNA damage TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 500 ug/L REFERENCE : AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 18,50,1980
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 14 nmol/L REFERENCE : ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 49,79,1989
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 50 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,257,1985
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Mammal - species unspecified Cells - not otherwise
specified
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Nethe