GW583340 DIHYDROCHLORIDE
CAS 388082-81-3 MFCD07370137
化学结构图
SMILES: Cl.Cl.CS(=O)(=O)CCNCC1=NC(=CS1)C1=CC2C(NC3C=C(Cl)C(=CC=3)OCC3C=C(F)C=CC=3)=NC=NC=2C=C1
化学属性
| Mol. Formula | C28H25ClFN5O3S2· 2HCl |
|---|---|
| Mol. Weight | 671.03 |
| Melting Point | 259.8-262.4 °C(lit.) |
别名和识别编码
| Chemical Name | GW583340 dihydrochloride |
|---|---|
| Synonym | 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride |
| MDL Number | MFCD07370137 |
| PubChem Substance ID | 24895131 |
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分类
- {SNA} Approved Therapeutics/Drug Ca
- {SA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors
- Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), G, GlaxoSmithKline, Kinase/Phosphatase Biology, P to Q, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
相关文献及参考
- Gaul, M.D., et al., Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg. Med. Chem. Lett. 13 , 637-640, (2003)
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
