Prostaglandin F2a Tris Salt 地诺前列素氨丁三醇

CAS 38562-01-5 MFCD00077863

化学结构图

38562-01-5
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C[C@H]1O.NC(CO)(CO)CO

化学属性

Mol. FormulaC20H34O5· C4H11NO3
Mol. Weight475.62

别名和识别编码

Chemical NameProstaglandin F2a Tris Salt
Synonym (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt PGF2α-Tris (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt PGF2α-Tris Prostaglandin F2α tris salt (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt PGF2α-Tris (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt PGF2α-Tris Prostaglandin F2α tris salt 7-(3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic acid, PGF2α-Tris
CAS Number38562-01-5
PubChem Substance ID24898587
EC Number254-002-3
Beilstein Registry Number4087514
MDL NumberMFCD00077863
Chemical Name Translation地诺前列素氨丁三醇
Wiswesser Line NotationL5TJ AQ B2U4VQ C1U1YQ5 DQ
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分类

  • {SNA} Analytical Standards,
  • {SNA} Allium sativum (Garlic),
  • {SNA} Arachidonic Acid Cascade, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids in Cell Signaling, Prostaglandins, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 脂类
  • {SNA} Allium sativum (Garlic), Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls,

相关文献及参考

  • [2]. Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868.
  • 1. Fuchs, A.R., Prostaglandin F 2α and oxytocin interactions in ovarian and uterine function. J. Steroid Biochem. 27 , 1073-1080, (1987) 摘要
  • Fujii, K., et al., Evidence that PGF2 alpha-induced contraction of isolated guinea pig bronchi is mediated in part by release of tachykinins J. Appl. Physiol. 75 , 1411-1418, (1995) 摘要
  • Merck 14 ,7878
  • Rapicavoli, N.A., et al., The Long Noncoding RNA RNCR 2 Directs Mouse Retinal Cell Specification. BMC Cell Biol. , (2010)
  • Sales KJ, Maldonado-Pérez D, et. al., Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway. Biochim. Biophys. Acta 1793 , 1917-1928, (2009) 摘要
  • [1]. Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSUK8025000
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Risk Statements
  • R60 May impair fertility 可能降低生殖能力
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 665 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Skin and Appendages - hair
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,1129,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,327,1982

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 711 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 21,623,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 101 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TOIZAG Toho Igakkai Zass

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - pig
DOSE                    : 333 ug/kg
SEX/DURATION            : female 20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 32,929,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : female 18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 12,1053,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 380 ug/kg
SEX/DURATION            : female 11 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 5,303,1972

TYPE OF TES

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 14,447,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSE

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Fatty Acyls - Lipids
  5. Eicosanoids (Prostaglandins, Leukotrienes) - Fatty Acyls
  6. Prostaglandins - Eicosanoids (Prostaglandins, Leukotrienes)
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Fatty Acyls - Lipids
  5. Eicosanoids (Prostaglandins, Leukotrienes) - Fatty Acyls
  6. Prostaglandins - Eicosanoids (Prostaglandins, Leukotrienes)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Prostaglandin Receptor  (前列腺素受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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