(4Ar,6R,7R,7As)-6-(6-Amino-9H-Purin-9-Yl)-2,7-Dihydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinine2-Oxide,SodiumSalt (4aR,6R,7R,7aS)-6-(6-氨基-9H-嘌呤-9-基)-2,7-二羟基四氢-4H-呋喃[3,2-d][1,3,2]二氧杂膦2-氧化物钠盐
CAS 37839-81-9 MFCD00069736
化学结构图
SMILES: [Na+].NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O |&1:11,13,20,21|
化学属性
| Mol. Formula | C10H11N5O6PNa |
|---|---|
| Mol. Weight | 369 |
| TSCA | No |
别名和识别编码
| Chemical Name | (4Ar,6R,7R,7As)-6-(6-Amino-9H-Purin-9-Yl)-2,7-Dihydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinine2-Oxide,SodiumSalt |
|---|---|
| Synonym | 3',5'-Amp sodium salt 3,5-Cyclic AMP sodium salt 3′,5′-Cyclic AMP sodium salt Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate Cyclic 3',5'-(hydrogen phosphate)adenosine monosodium salt Cyclic 3',5'-amp sodium salt cAMP-Na 环化腺苷酸 钠盐 腺苷-3′,5′-环单磷酸 钠盐 一水合物 |
| MDL Number | MFCD00069736 |
| PubChem Substance ID | 87560483 |
| Beilstein Registry Number | 5215289 |
| CAS Number | 37839-81-9 |
| Reaxys-RN | 5215289 |
| Chemical Name Translation | (4aR,6R,7R,7aS)-6-(6-氨基-9H-嘌呤-9-基)-2,7-二羟基四氢-4H-呋喃[3,2-d][1,3,2]二氧杂膦2-氧化物钠盐 |
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资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Nucleotide, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Nucleosides, Nucleotides, Oligonucleotides, Nucleotides
- A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and
相关文献及参考
- Giusti, C., et al., Necrotic Cell Death: From Reversible Mitochondrial Uncoupling To Irreversible Lysosomal Permeabilization. Exp. Cell Res. 315 , 26-38, (2009) 摘要
- Dreier, B., and Plückthun, A., Ribosome Display: A Technology For Selecting And Evolving Proteins From Large Libraries. Methods Mol. Biol. 687 , 283-306, (2011) 摘要
- Tuganowski, W. and Kopeć, P., Effect of exogenous cAMP in the rabbit right auricle Pol. J. Pharmacol. Pharm. 30 , 451-4, (1978)
- Dunzendorfer, U. and Knöner, M., Effect of high level bovine parathyroid extracts on serum PTH, cAMP and urinary cAMP, Na + , and uric acid in stone-forming patients Eur. Urol. 8 , 363-6, (1982)
- Beese, M., et al., Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells BMC Cell Biol. 11 , 68, (2010)
- Daniel, P.B., et al., Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18 , 353-383, (1998)
- Spada, A., et al., Cyclic AMP and calcium in the transduction of hypothalamic neurohormone action in human pituitary tumors. Horm. Res. 47 , 235-239, (1997) 摘要
- Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78 , 165-174, (1998) 摘要
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14300 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 645 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 395 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
