Buflomedil Hydrochloride 4-(1-吡咯烷基)-1-(2,4,6-三甲氧基苯基)-1-丁酮盐酸盐
CAS 35543-24-9 MFCD35543249
化学结构图
SMILES: COC1C=C(C=C(OC)C=1C(=O)CCCN1CCCC1)OC
化学属性
| Mol. Weight | 344 |
|---|---|
| Mol. Formula | C17H26ClNO4 |
别名和识别编码
| CAS Number | 35543-24-9 |
|---|---|
| Chemical Name | Buflomedil Hydrochloride |
| Synonym | Buflan Loftyl Irrodan R Buflonat Bufedil Provas Irrodan Fonzylane Buflocit Buflomedil hydrochloride 4-(1-Pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone Hydrochloride A-48257 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride LL 1656 Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3) propylacetone Lofton |
| Chemical Name Translation | 4-(1-吡咯烷基)-1-(2,4,6-三甲氧基苯基)-1-丁酮盐酸盐 |
| MDL Number |
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Aromatics
- Heterocyclic
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Buflomedil is used as an vasodilator (peripheral).
相关文献及参考
- Gundert-Remy, U., et al.: Eur. J. Clin. Pharmacol., 20, 459 (1981),
- Rosas, G., et al.: Angiology, 32, 291 (1981),
- Clissold, S.P., et al.: Drugs, 33, 430 (1987),
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 216 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - other changes REFERENCE : ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 22,57,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 410 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : KSRNAM Kiso to Rinsho. Clinical Repo
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Behavioral - coma REFERENCE : ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 22,57,1996
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) REFERENCE : ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 20,219,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1500 mg/kg SEX/DURATION : female 17-22 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 22,473,1988
