Daphnetoxin,12-((1-oxo-5-phenyl-2,4-pentadienyl)oxy)-,(12-beta(E,E))-
CAS 34807-41-5 MFCD00135953
化学结构图
SMILES: C[C@@H]1[C@@H](OC(=O)/C=C/C=C/C2C=CC=CC=2)[C@@]2(O[C@@]3(O[C@@]41[C@@H]1C=C(C)C(=O)[C@@]1(O)[C@H](O)[C@@]1(CO)O[C@H]1[C@H]4[C@H]2O3)C1C=CC=CC=1)C(C)=C
化学属性
| Mol. Formula | C38H38O10 |
|---|---|
| Mol. Weight | 654.70 |
| TSCA | No |
别名和识别编码
| Chemical Name | Mezerein |
|---|---|
| Synonym | 12β-[(E,E)-5-Phenyl-2,4-pentadienoyloxy]daphnetoxin Meserein Mezerein |
| MDL Number | MFCD00135953 |
| PubChem Substance ID | 24897019 |
| Beilstein Registry Number | 1675867 |
| CAS Number | 34807-41-5 |
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分类
- {SNA} Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, M, Protein Kinase Activators, Tumor Growth Regulation, Tumor Promotors
- {SNA} Kinase/Phosphatase Biology, Protein Kinase Activators, Tumor Promotors, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节
安全信息
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S22 Do not breathe dust 不要吸入粉尘；
- R38 Irritating to skin 刺激皮肤
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3560 ug/kg/20W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - primary irritation (after topical exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,4791,1979
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - primary irritation (after topical exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,4791,1979
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Rodent - mouse DOSE/DURATION : 340 nmol/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,4126,1983
TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Rodent - mouse DOSE/DURATION : 340 nmol/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,4126,1983
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - mouse Fibroblast DOSE/DURATION : 100 ug/L REFERENCE : FACOEB Food Additives and Contaminants. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1984- Volume(issue)/page/year: 1,179,1984
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 16 nmol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,1507,1983
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 20 mg/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 294,263,1981
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 100 nmol/L REFERENCE : CNREA8 Cancer Research
