2-(benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)imino)-1,2-dihydropyrimidin-4-yl)acetonitrile 2-(苯并[d]噻唑-2-基)-2-(2-((2-(吡啶-3-基)乙基)亚氨基)-1,2-二氢嘧啶-4-基)乙腈
CAS 345987-15-7 MFCD45987157
化学结构图
SMILES: N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1
化学属性
| Mol. Weight | 372.45 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 2-(苯并[d]噻唑-2-基)-2-(2-((2-(吡啶-3-基)乙基)亚氨基)-1,2-二氢嘧啶-4-基)乙腈 |
|---|---|
| Chemical Name | 2-(benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)imino)-1,2-dihydropyrimidin-4-yl)acetonitrile |
| Formula | C20H16N6S |
| Synonym | AS601245; AS-601245; AS 601245. |
| IUPAC Name | (Z)-2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile |
| InChIKey | AVLYNJZZQYEFEA-XDJHFCHBSA-N |
| InChI | InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+ |
| Canonical SMILES | N#C/C(C1=NC(NCCC2=CC=CN=C2)=NC=C1)=C3SC4=CC=CC=C4N\3 |
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产品应用
- AS601245 is a potent and selective JNK inhibitor. AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells. AS601245 and clofibrate have a synergistic effect in inducing cell responses and in affecting the cene expression profile in CaCo-2 colon cancer cells. AS601245 reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils. AS601245 shows promising neuroprotective properties.
