Acebutolol hydrochloride 醋丁洛尔
CAS 34381-68-5 MFCD00078860
化学结构图
SMILES: Cl.CC(=O)C1C=C(C=CC=1OCC(O)CNC(C)C)NC(=O)CCC
化学属性
| Mol. Formula | C18H28N2O4.ClH |
|---|---|
| Mol. Weight | 372.94 |
别名和识别编码
| Chemical Name | Acebutolol hydrochloride |
|---|---|
| CAS Number | 34381-68-5 |
| Synonym | Acebutolol hydrochloride N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide Hydrochloride Acetobutolol hydrochloride dl-1-(2-Acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane 醋丁洛尔 盐酸盐 DL-1-(2-Acetyl-4-butyramido)-3-(isopropylamino)propan-2-ol Hydrochloride |
| MDL Number | MFCD00078860 |
| PubChem Substance ID | 24890799 |
| EC Number | 251-980-3 |
| Wiswesser Line Notation | 3VMR CV1 DO1YQ1MY1&1 &GH |
| Chemical Name Translation | 醋丁洛尔 |
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分类
- A, AA to AL, Alphabetic, Analytical Standards, Analytical/Chromatography, Beta-Blockers, Chromatography, Doping Substances, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds
- {SNA} Alphabetical Index of Analytical Standards, A, AA to AL, All Doping Standards (A-Z), Analytical Standards, Analytical/Chromatography, Beta Blockers, Chromatography, Doping Substances, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds
产品应用
- Cardioselective ?-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
相关文献及参考
- [2]. Bristow MR, et al. Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology. Circ Res. 2011 Oct 28;109(10):1176-94.
- [3]. Mostafavi, S., R. Lewanczuk, and R. Foster, Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats. Biopharm Drug Dispos, 2000. 21(4): p. 121-8.
- Cuthbert, O.A., et al.: Br. J. Pharmacol., 43, 639 (1971),
- Foster, R.T., et al.: Anal. Profiles Drug Subs., 19, 1 (1990),
- Merck 14 ,19
- Singh, B.N., et al.: Drugs, 29, 531 (1985),
- [1]. Piquette-Miller, M. and F. Jamali, Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats. Biopharm Drug Dispos, 1997. 18(6): p. 543-56.
- [1]. Piquette-Miller, M. and F. Jamali, Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats. Biopharm Drug Dispos, 1997. 18(6): p. 543-56.
- [2]. Bristow MR, et al. Treatment of chronic
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H332 Harmful if inhaled 吸入有害
- H312 Harmful in contact with skin 皮肤接触有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 103 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-9
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4050 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1310 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,837,1978
{hazard_cTYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 6,512,1988
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1100 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - delayed effects REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,885,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 22 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,885,1978
