CAS 330-55-2 MFCD00055249-Linuron solution 利谷隆 TAO{mole}

Linuron solution 利谷隆

CAS 330-55-2 MFCD00055249

化学结构图

SMILES: CON(C)C(=O)Nc1ccc(Cl)c(Cl)c1

化学属性

Mol. Formula	C9H10Cl2N2O2
Mol. Weight	249
Melting Point	93-94°C
Boiling Point	180-190 ºC
Solubility	0.0075 G/100 ML
Flash Point	11 °C
Density	1.49

别名和识别编码

Chemical Name	Linuron
MDL Number	MFCD00055249
Beilstein Registry Number	2128725
CAS Number	330-55-2
EC Number	206-356-5
Synonym	AFALON(R) N'-(3,4-Dichlorophenyl)-N-metho Aphalon AFALON N-(3,4-Dichlorophenyl)-N'-methyl-N'-methoxyurea {hazar 1-甲氧基-1-甲基-3-(3,4-二氯苯基)脲 LOROX(R) LOROX 1-methoxy-1-methyl-3-(3,4-dichlorophenyl)urea Linuron Du Pont 326 LINNET Linex 4L LINUREX 1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea HOE 2810 Linurex Scarclex Herbicide 326 Lorox Cephalon 3-(3,4-Dichlor-phenyl)-1-methoxy-1-methyl-harnstoff N-(3,4-二氯苯基)-N'-甲氧基-N'-甲基脲 3-(3，4-二氯苯基)-l-甲氧基-1-甲基脲 1-(3,4-Dichlorophenyl)3-methoxy-3-methyluree n-(3,4-dichlorophenyl)-n'-methoxy-n'-methylurea N-(3,4-二氯苯基)-N’-甲氧基-N’-甲基脲 Lorox linuron weed killer Sarclex Linorox Afalon 3-(3,4-Dichloro-fenil)-1-metossi-1-metil-urea 利谷隆溶液 3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea Garnitan Afalon inuron 直西龙 LINEX 'LGC' (1404) Dupont herbicide 326 3-(3,4-Dichlorophenyl)-1-methoxymethylurea AGRO-KIMOLIN 3-(3,4-Dichloor-fenyl)-1-methoxy-1-methylureum DUPONT HERBICIDE 326 1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea; 3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea; N-(3,4-Dichlorophenyl)-N'-methoxy-N'-methylurea SIOLCID LINURON CEPHALON N-(3,4-Dwuchlorofenylo)N'-metoksy-N'-metylomocznik 3-(4,5-Dichlorphenyl)-1-methoxy-1-methylharnstoff TELIRON Laroks PROVIGIL Methoxydiuron
Chemical Name Translation	利谷隆
Wiswesser Line Notation	GR BG DMVN1&O1
PubChem Substance ID	9502
InChI	InChI=1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)

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分类

2000/60/EC, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chr
{SNA} 2000/60/EC, Additional Standards, Analytical Standards, EPA, Endocrine Disruptors (Draft), European Community: ISO, DIN and DL 152, Food and Cosmetic Component Standards, H-M, Method and Regulation Specific, Pesticides, Bactericides, Fungicides and Disinfectants, Standards for Personal Care and Cosmetic Products, Urea structure, neats, prohibited substances (EU-REGULATION No 1223/2009), 农残和代谢标准品, 分析/色谱, 按照字母排序, 灭草剂
{SNA} 2000/60/EC, Additional Standards, Analytical Standards,

产品应用

利谷隆可用于玉米、小麦、棉花、大豆、高粱、花生、豌豆、马铃薯、陆稻、向日葵、甘蔗、亚麻以及多种蔬菜和果树、森林苗圃等作物田中防治种利单、双子叶杂草以及某此多年生杂草。

安全信息

RTECSYS9100000

GHS Symbol

WGK Germany3

Precautionary statements

P301+P310
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P308+P313
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P273 Avoid release to the environment. 避免释放到环境中。
P201 Obtain special instructions before use. 使用前获取专门指示。

Hazard statements

H370 Causes damage to organs 导致器官损伤
H331 Toxic if inhaled 吸入中毒
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H311 Toxic in contact with skin 皮肤接触中毒
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H351 Suspected of causing cancer 怀疑致癌
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H302 Harmful if swallowed 吞食有害
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

Hazard Codes T,N F,T T;N T;N,N,T,F

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Risk Statements

R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R48/22
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R22 Harmful if swallowed 吞咽有害
R50/53

UN Number 3077 UN 3077

Storage condition APPROX 4°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1146 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,299,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

{h

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Project

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,520,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,299,1986

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,353,1978

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 4500 mg/kg/2W (Intermittent)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 390,207,1997

其他信息

外观性质:固体。
储运特性:库房通风低温干燥; 与食品原料分开储运
产品特性:选择性芽前、芽后脲类除草剂。遇酸、碱、在潮湿土壤中或在高温下都会分解。低毒。具有内吸和触杀作用。主要通过杂草的根部吸收，也可被叶片吸收。
类别:农药
MSDS 信息:利谷隆(330-55-2).msds
用途三:利谷隆可用于玉米、小麦、棉花、大豆、高粱、花生、豌豆、马铃薯、陆稻、向日葵、甘蔗、亚麻以及多种蔬菜和果树、森林苗圃等作物田中防治种利单、双子叶杂草以及某此多年生杂草。
上游原料:硫酸二甲酯 --> 搪玻璃反应锅 --> 硫酸羟胺 --> 原粉 --> 3,4-二氯苯异氰酸酯 --> 羟基脲
MOL 文件:330-55-2.mol
职业标准:STEL 1 毫克/ 立方米
用途一:属脲类除草剂，可用于大豆、玉米、棉花、胡萝卜、芹菜、小麦、花生、甘蔗、果树等作物
毒性分级:中毒
图谱信息:利谷隆(330-55-2)红外图谱(IR2) 利谷隆(330-55-2)核磁图( 1 HNMR) 利谷隆(330-55-2)核磁图( 13 CNMR) 利谷隆(330-55-2)红外图谱(IR1) 利谷隆(330-55-2)质谱(MS)
Sigma Aldrich:330-55-2(sigmaaldrich)
用途:利谷隆制剂为50%可湿性粉剂。用于大豆、玉米、高梁、棉花马铃薯、胡萝卜、芹菜、水稻、小麦、花生、甘蔗、果树、葡萄以及苗圃等地，防治稗草、牛筋草、狗尾草、马唐、蓼、藜、马齿苋、鬼针草、苋菜、猪殃殃、眼子菜、豚草等。大豆、玉米、高梁地，每公顷用50%可湿性粉剂2250~3000克进行苗前土壤处理；或用1200克加1500克48%拉索乳油喷雾土壤处理；也可与杜耳、毒草胺混用；大豆田还可与氯乐灵混用土壤处理。大豆田使用，要求播种深度为4~5厘米，过浅易产生药害。棉田使用，每公顷用50%可湿性粉剂1875~2250克进行播后苗前土壤处理，过量，易产生药害。冬小麦田使用，播后苗前每公顷用1500~1950克喷雾土壤处理。水稻田，每公顷用1200~1500克防治眼子菜。苗后茎叶处理，药液中加入0.6%表面活性剂，喷药位置不得超过作物高度的1/3，防止药液落到作物叶面上产生药害。土壤有机质含量低于1%或高于5%的田块不宜使用；砂性重，雨水多的地区不宜使用。敏感作物有甜菜、向日葵、甘蓝、莴苣、甜瓜、小萝卜、烟草、茄子、辣椒等。喷雾器具使用后要清洗干净。
急性毒性:口服- 大鼠 LD50: 1146 毫克/ 公斤; 口服- 小鼠 LD50: 2400 毫克/ 公斤
用途二:利谷隆可用于玉米、小麦、棉花、大豆、高粱、花生、豌豆、马铃薯、陆稻、向日葵、甘蔗、亚麻以及多种蔬菜和果树、森林苗圃等作物田中防治种利单、双子叶杂草以及某此多年生杂草。大白鼠口服LD为4000mg/kg。
可燃性危险特性:燃烧产生有毒氮氧化物和氯化物气体
灭火剂:干粉、泡沫、砂土
方法一:由3，4-二氯苯异氰酸酯与硫酸羟胺反应生成3，4-二氯苯羟基脲，然后与硫酸二甲酯反应制得利谷隆。1.3，4-二氯苯羟基脲的制备将3，4-二氯苯异氰酸酯-甲苯溶液、硫酸羟胺水溶液、氢氧化钠溶液按计算量分别抽入各计量槽。将水和硫酸羟胺同时加入搪玻璃反应锅，搅拌冷却，在20℃左右开始滴加氢氧化钠溶液，约1h滴完，温度控制在20℃左右，滴加完毕pH在7.5-7.9之间（否则补加氢氧化钠或硫酸羟胺）。然后开始滴加3，4-二氯苯异氰酸酯-甲苯溶液，此时控制温度30±2℃，约1.5h内滴完，并在此温度下继续反应2h。静置2h后，将上层甲苯清液抽出。下层物料加水搅拌后进行离心分离，得固体湿品3，4-二氯苯羟基脲。收率87%。2.利谷隆的制备将上述湿品羟基脲加入搪坡璃反应釜，然后加入计算量的硫酸二甲酯，搅拌20min。滴加20%的氢氧化钠溶液，温度控制在20-30℃，约1.5h内滴加完毕。在30℃左右反应2h，至pH7为反应终点，若偏酸性时，可适当补加氢氧化钠。反应结束后加水搅拌，甩滤，干燥，即得利谷隆原粉。收率90%。
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