CAS 32795-47-4 MFCD00069320-2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine Maleate 2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺马来酸盐 TAO{mole}

2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine Maleate 2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺马来酸盐

CAS 32795-47-4 MFCD00069320

化学结构图

SMILES: CN1CC2=C(N)C=CC=C2C(C1)C1C=CC=CC=1.OC(=O)/C=C\C(O)=O

化学属性

Mol. Formula	C16H18N2· C4H4O4
Mol. Weight	354.40

别名和识别编码

Chemical Name	2-Methyl-4-Phenyl-1,2,3,4-Tetrahydroisoquinolin-8-Amine Maleate
Synonym	1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, Alival (antidepressant) HOE 984 Hostalival Nomifensine maleate salt
MDL Number	MFCD00069320
PubChem Substance ID	24277920
EC Number	251-223-7
Chemical Name Translation	2-甲基-4-苯基-1,2,3,4-四氢异喹啉-8-胺马来酸盐
Wiswesser Line Notation	T66 CNT&J C1 ER& JZ &QV1U1VQ
CAS Number	32795-47-4

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分类

{SNA} Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, N, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives
{SNA} Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, N, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子,

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

RTECSNX4912800

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 854 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,45,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >32 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,45,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sen

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 28,171,1984