CAS 32780-64-6 MFCD00057663-Labetalol Hydrochloride 盐酸拉贝洛尔 TAO{mole}

Labetalol Hydrochloride 盐酸拉贝洛尔

CAS 32780-64-6 MFCD00057663

化学结构图

SMILES: Cl.CC(CCC1C=CC=CC=1)NCC(O)C1=CC(=C(O)C=C1)C(N)=O

化学属性

Mol. Formula	C19H24N2O3· HCl
Mol. Weight	364.87

别名和识别编码

Chemical Name	Labetalol Hydrochloride
Synonym	5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)salicylamide 2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide hydrochloride Labetalol hydrochloride Amipress AH 5158A
MDL Number	MFCD00057663
PubChem Substance ID	24278510
EC Number	251-211-1
Wiswesser Line Notation	ZVR BQ EYQ1MY1&2R &GH
CAS Number	32780-64-6
Chemical Name Translation	盐酸拉贝洛尔

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分类

{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, L, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Schering Plough, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagent

安全信息

RTECSCV5376000

WGK Germany3

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 41 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   HOIZAK Hokkaido Igaku Zasshi.  Hokkaido Journal of Medical Science.
   (Hokkaido Daigaku Igakubu, Nishi-7-chome, Kita-15-jo, Kita-ku, Sapporo,
   Japan)  V.1-    1923-  Volume(issue)/page/year: 53,15,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   HOIZAK Hokkaido Igaku Zasshi.  Hokkaido Journal of Medical Science.
   (Hokkaido Daigaku Igakubu, Nishi-7-chome, Kita-15-jo, Kita-ku, Sapporo,
   Japan)  V.1-    1923-  Volume(issue)/page/year: 53,15,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 53 mg/kg/53D-I
TOXIC EFFECTS :
   Liver - jaundice (or hyperbilirubinemia) hepatocellular
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AIMEAS Annals of Inte

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   6,273,1980

{hazar

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 600 ug/kg
SEX/DURATION            : female 35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - respiratory system
   Reproductive - Effects on Newborn - Apgar score (human only)
REFERENCE :
   AJPEEK American Journal of Perinatology.  (Thieme Medical Publishers, Inc.
   381 Park Ave. S., New York, NY  10157-0208)  V.1-    1983-
   Volume(issue)/page/year: 11,91,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3150 mg/kg
SEX/DURATION            : male 63 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 9,839,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 9,869,1981

TYPE OF TEST            : TDLo - Lowest

TYPE