CAS 318-98-9 MFCD00012558-1-(1-Naphthoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐 TAO{mole}

1-(1-Naphthoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐

CAS 318-98-9 MFCD00012558

化学结构图

SMILES: CC(C)NCC(O)COc1cccc2ccccc12.Cl

化学属性

Mol. Formula	C16H21NO2· HCl
Mol. Weight	295.80
Density	1.422
Melting Point	163-165°
TSCA	No
Solubility	可溶
Appearance	白色或类白色的结晶性粉末；无臭，味微甜后苦。盐酸普萘洛尔(318-98-9)在水或乙醇中溶解，在氯仿中微溶。 powder
Stability	对光敏感

别名和识别编码

Chemical Name	1-(1-Naphthoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
CAS Number	318-98-9
Alfabeta Name	PROPRANOLOLHYDROCHLORIDE
MDL Number	MFCD00012558
Synonym	(±)-1-Isopropylamino-3- (+/- (+/-)-1-ISOPROPYLAMINO-3-(1-NAPHTHYLOXY)-2-PROPANOL HYDROCHLORIDE (+/-)-PROPRANOLOL HY (±)-Propranolol hydrochloride (±)-[2-hydroxy-3-(naphthyloxy)propyl]isopropylammonium chloride (±)-盐酸普萘洛尔,99% 1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-(Isopropylamino)-3-(1-naphthoxy)-2-propanol hydrochloride 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochlorid 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol hydrochloride 1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanohydrochloride 1-[ISOPROPYLAMINO]-3-[1-NAPHTHYLOXY]-2-PROPANOL HYDROCHLORIDE 1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐 1[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol Hydrochloride 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphth 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride AY 64043 AY-64043 Anaprilin Apsolol Avlocardyl Berkolol Beta Neg Caridolol Caridorol DL-Anapriline DL-PROPRANOLOL HCL 99% DL-PROPRANOLOL HYDROCHLORIDE Docitan Dociton Herzbase I 2065 Ikopal Inderal hydrochloride Inderol Kemi NCS-91523 Obsidan Oposim PROPANOLOL HYDROCH PROPRANOLOL HCL PROPRANOLOL HYDROCHLORIDE Propranolol chloride propranalol hydrochloride propranolol hydrochloride (INNM) {} {Chemicalbo {} {} {Chem {} {} {haz {Chemical
EC Number	206-268-7
Beilstein Registry Number	4164259
PubChem Substance ID	62882
Merck Number	14,7840
Chemical Name Translation	1-异丙氨基-3-(1-萘氧基)-2-丙醇盐酸盐
Wiswesser Line Notation	L66J BO1YQ1MY1&1 &GH
LabNetwork Molecule ID	LN00150905
InChI	InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

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分类

{uni_hamburg} no charge; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; alcohol; ether; racemate; 2fragments; ionic
{SA} Amino Alcohols, Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds
Pharmaceuticals
{SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, P, Proteins and Derivatives
Amines
{SNA} Adrenergics,
{SNA} Adrenergics, Adrenergics - Antagonists,

产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制

安全信息

Warnings IRRITANT

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H302 Harmful if swallowed 吞食有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSUB7525000

Hazard Codes Xn Xn,Xi

Storage condition 储存温度2-8°C 2-8°C

Packing GroupIII

Hazard Class6.1(b)

UN Number 3249

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 208 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 12(Suppl 6),969,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 417 mg/kg/1Y-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
   PRACAK Practitioner.  (Morgan-Grampian Ltd., 40 Beresford St., Woolwich,
   London SE18 6BQ, UK) V.1-    1868-  Volume(issue)/page/year: 229,663,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,733,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   PSCHDL Psychopharmacology (Berlin).  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.47-    1976-
   Volume(issue)/page/year: 79,148,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 48 mg/kg
SEX/DURATION            : female 25-34 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   91,808,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 10500 ug/kg
SEX/DURATION            : female 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 12,53,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       :

其他信息

Sigma Aldrich:3506-09-0(sigmaaldrich)