CAS 315-37-7 MFCD00055890-Testosterone Enanthate 庚酸睾酮 TAO{mole}

Testosterone Enanthate 庚酸睾酮

CAS 315-37-7 MFCD00055890

化学结构图

SMILES: CCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

化学属性

Mol. Formula	C26H40O3
Mol. Weight	400.66
Melting Point	34-39 ºC
Appearance	白色结晶性粉末。熔点为34-36℃。
Density
Boiling Point

别名和识别编码

Chemical Name	Testosterone Enanthate
Synonym	17-Hydroxyandrost-4-en-3-one, 17-heptanoate 17-[(1-Oxoheptyl)oxy]androst-4-en-3-one 17BETA-HYDROXY-4-ANDROSTEN-3-ONE 17-ENANTHATE 17b-hydroxyandrost-4-en-3-one-17-ethanate 3-Oxoandrost-4-en-17-yl heptanoate 4-ANDROSTEN-17-BETA-OL-3-ONE ENANTHATE 4-ANDROSTEN-17BETA-OL-3-ONE 17-ENANTHATE Andro L.A. 200 Androst-4-en-3-one, 17-((1-oxoheptyl)oxy)-, (17-beta)- Androst-4-en-3-one, 17-[(1-oxoheptyl)oxy]-, (17beta)- Androst-4-en-3-one, 17beta-hydroxy-, heptanoate Androtardyl Atlatest Delatestryl Heptanoic acid, ester with testosterone Malogen L.A.200 NSC-17591 Reposo TMD TESTOSTERONE ENANTATE TESTOSTERONE ENANTHATE TESTOSTERONE HEPTANOATE TESTOSTERONE HEPTYLATE Testenate Testosterone 17-enanthate Testosterone enanthate Testosterone heptanoate; 17b-Hydroxyandrost-4-en-3-one-17-ethanate Testosterone heptylate Testosterone oenanthate component of Androgyn l.a. component of Deladumone component of Ditate component of Mal-O-Fem L.A 庚酸睾丸素庚酸睾酮睾丸激素庚酸酯睾酮庚酸酯
MDL Number	MFCD00055890
PubChem Substance ID	9416
EC Number	206-253-5
CAS Number	315-37-7
Chemical Name Translation	庚酸睾酮
Wiswesser Line Notation	L E5 B666 OV MUTJ A E FOV6
Beilstein Registry Number	3170544
InChI	InChI=1S/C26H40O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h17,20-23H,4-16H2,1-3H3/t20-,21-,22-,23-,25-,26-/m0/s1

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安全信息

RTECSXA3080000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308 IF exposed or concerned: 如果接触或涉及

Hazard statements

H350 May cause cancer 可能致癌
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Danger

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Hazard Codes T

Risk Statements

R45 May cause cancer 可能致癌
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

Storage condition 2-8°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 409 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,474,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1770 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 755 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Ja

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,805,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE                    : 20 mg/kg
SEX/DURATION            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 630 mg/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   67,131,1993

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 35455 ug/kg
SEX/DURATION            : female 4-14 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 6,21,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 36 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ANENAG Annales d'Endocrinologie.  (Masson Editeur, 120 Blvd. Saint-Germain,
   F-25280 Paris Cedex 06, France)  V.1-    1939-  Volume(issue)/page/year:
   17,118,1956

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Ma

UN Number

Packing Group

其他信息

雄性激素类药物:庚酸睾酮为雄性激素类药物，是睾酮丙酸酯与睾酮庚酸酯的复合制剂。作用与丙酮睾酮相同，能促进男性性器官及副性征的发育，对抗雌激素。还有蛋白同化作用，可使肌肉增长、体重增加等。作用快，且持续时间较长，注射250mg可维持药效2～4周。临床上适用于治疗男性性腺机能不全、性器官发育不良、不育症、无睾症和稳睾症等;也可用于女性功能性子宫出血、更年期综合征、乳腺癌和性器官癌;肝硬化、再生障碍性贫血、骨质疏松症等;消耗性疾病。【不良反应】大剂量或长期使用，可引起水钠潴留和水肿现象。青年女性可出现男性化现象，如嗓音变粗、多毛、痤疮、阴蒂肥大等。前列腺癌、孕妇禁用。前列腺肥大及肝、肾功能障碍者慎用庚酸睾酮。治疗乳腺癌时，如发现血钙过高应立即停药。
男性避孕药:庚酸睾酮即是一种激素酯，它能抑制脑垂体，促进性腺素释放，从而使睾丸间质细胞分泌的内源睾酮下降，最终达到阻断精子发生的目的。中科院动物所在对猴子进行试验时发现，每周注射１次庚酸睾酮，一周后猴子的精细胞开始凋亡，到第五周精细胞凋亡达到高峰。对308位志愿者的临床试验还表明，庚酸睾酮避孕药对亚洲男性的作用明显高于白种人。在这项研究中，虽然精子的减少率并未呈现种族间的差异，但亚洲人比白种人对激素导致的精子发生抑制更为敏感，９５％以上的亚洲人可达到无精子，而只有40%至70%的白种人成为无精子。庚酸睾酮是一种长效男性避孕药，可通过多种途径给药(每周2次至每3周1次，每次200～500mg，肌内注射) ，通过对100余例志愿者试用，结果表明，每周肌内注射250mg，10周后可使大多数男子产生无精子症或严重少精子症，停药一定时间后精子数均可恢复，不良反应同前。如将注射间隔延长至10～12d以上，用加倍剂量效果也不理想。药代动力学研究表明，本品注射后当即产生一个超生理水平的血高峰，此后血浓度迅速下降，说明每周给药的必要; 此项血高峰有可能直接刺激生精，故部分志愿者未能达到明显少精子症，少数志愿者精子密度下降后可再次上升。庚酸睾酮只需每周注射1次，似比丙酸睾酮优越; 但即使如此，也甚难为多数人所接受。其他两种睾酮制剂，即环戊丙酸睾酮及环己烷羧酸睾酮，亦需每周注射1次。
Sigma Aldrich:315-37-7(sigmaaldrich)
比旋光度:77 °
用途一:临床用于治疗男性性机能减退，再生障碍性贫血等病症
用途二:临床用于男性机能减退，再生障碍性贫血等。
MOL 文件:315-37-7.mol