CAS 314-13-6 MFCD00004021-Evans Blue 伊文思蓝 TAO{mole}

Evans Blue 伊文思蓝

CAS 314-13-6 MFCD00004021

化学结构图

SMILES: Cc1cc(-c2ccc(/N=N/c3ccc4c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c(N)c4c3O)c(C)c2)ccc1/N=N/c1ccc2c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c(N)c2c1O.[Na+].[Na+].[Na+].[Na+]

化学属性

Mol. Formula	C34H24N6Na4O14S4
Mol. Weight	960.81
TSCA	Yes
Solubility	280 G/L (20 ºC)

别名和识别编码

Chemical Name	Evans Blue
MDL Number	MFCD00004021
CAS Number	314-13-6
Synonym	1,3-Naphthalenedisulfonicacid,6,6’-[[3,3’-dimethyl(1,1’-biphenyl)-4,4’-diyl]bis(azo)]bis(4-amino-5-hydroxy-,tetrasodiumsalt Azovan Blue Blue, Azovan Blue, Evan's Blue, Evans C.I. 23860 C.I. Direct Blue 53 Direct Blue 53 EVAN'S BLUE Evan Blue Evan's Blue Evans Blue Evans blue (Technical Grade) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 依文氏兰
PubChem Substance ID	9409
EC Number	206-242-5
Merck Number	3905
Chemical Name Translation	伊文思蓝
Reaxys-RN	7110512
Beilstein Registry Number	16(2)259
Wiswesser Line Notation	L66J BZ CSWO ESWO JQ INUNR B1 DR C1 DNUN- IL66J BZCSWO ESWO JQ &-NA- 4
LabNetwork Molecule ID	LN01742147
InChI	InChI=1S/C34H28N6O14S4.4Na/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4
Canonical SMILES	CC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(C)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5

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产品应用

本品为诊断用药，用于测定血溶量。

安全信息

Hazard statements

H301 Toxic if swallowed 吞食有毒
H350 May cause cancer 可能致癌

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Hazard Codes T F;T T,F

Packing GroupIII

UN Number

RTECSQJ6440000

Storage condition +4°C 2-8°C 4℃ Store at RT. 密封阴凉干燥保存。

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 850 mg/kg/34W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Blood - leukemia
REFERENCE :
   APHGBP Acta Pathologica (Belgrade).  (Belgrade Univerzitet, Institute de
   Pathologie, Belgrade, Yugoslavia)  V.2/3-    1938- Volume(issue)/page/year:
   33,1,1953

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1 mL/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ARSUAX Archives of Surgery (Chicago).  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-61, 1920-50; V.81-    1960-  Volume(issue)/page/year:
   48,17,1944

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 340 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 136,64,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 mL/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ARSUAX Archives of Surgery (Chicago).  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-61, 1920-50; V.81-    1960-  Volume(issue)/page/year:
   48,17,1944

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3 mL/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ARSUAX Archives of Surgery (Chicago).  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-61, 1920-5

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 192 umol/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,231,1984

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,101,1985

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,255,1984

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MDMIAZ Medycyna Doswiadczalna i Mikrobiologia.  For English translation, see
   EXMMAV.  (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)  V.1-    1949-
   Volume(issue)/page/year: 31,11,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,21,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 127,215,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 127,215,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 140 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 2,85,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous

其他信息

图谱信息:伊文思蓝(314-13-6)红外图谱(IR2) 伊文思蓝(314-13-6)红外图谱(IR1)
EPA化学物质信息:1,3-Naphthalenedisulfonic acid, 6,6'-[(3,3'-dimethyl[ 1,1'-biphenyl]-4,4'- diyl)bis(azo)]bis[4-amino- 5-hydroxy-, tetrasodium salt(314-13-6)
RTECS号:QJ6440000
色指数:23860
水中溶解度:280 g/L (20°C)，溶于乙醇、酸、碱；几乎不溶于苯、氯仿、乙醚。有吸湿性。在pH近于10时变色。
用途:本品为诊断用药，用于测定血溶量。
生产方法:由3，3'-二甲基联苯胺重氮化后与1-氨基-8-萘酚-2，4-二磺酸（1824酸）偶合而得。
稳定性:Stable. Incompatible with strong reducing agents, strong oxidizing agents.
伊文思蓝价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 71016588 依文思蓝 10g 160元 2011/04/16 E0197 伊文思蓝 Evans Blue 25G 717元 2010/06/21 195550250 伊文思蓝 Evans Blue 25 GR 1051元
MOL 文件:314-13-6.mol