CAS 31112-62-6 MFCD00010577-3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)benzamide 甲泛葡胺 TAO{mole}

3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)benzamide 甲泛葡胺

CAS 31112-62-6 MFCD00010577

化学结构图

SMILES: CC(=O)N(C)C1C(I)=C(C(I)=C(NC(C)=O)C=1I)C(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O

化学属性

Mol. Formula	C18H22I3N3O8
Mol. Weight	789.13
Melting Point	222-224 °C (dec.)(lit.)

别名和识别编码

Chemical Name	3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)benzamide
CAS Number	31112-62-6
Synonym	2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose Metrizamide Amipaque Telebrix 300 3-Acetylamino-5-N-methyl-acetylamino-2,4,6-triiodobenzoyl glucosamine 2-[3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzamido]-2-deoxy-D-glucose Metrizamide, mixture of anomers 2-((3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl)amino)-2-deoxy-D-glucose 2-(3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido)-2-deoxy-D-glucopyranose 2-(3-Acetamido-5-N-methyl-acetamido-2,4,6-triiodobenzamido)-2-deoxy-D-glucose 2-(3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido)-2-deoxy-D-glucose D-Glucose,
MDL Number	MFCD00010577
Beilstein Registry Number	6758226
EC Number	250-475-5
Chemical Name Translation	甲泛葡胺

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产品应用

Metrizamide is a X-ray contrast agent related to Metrizoic Acid (M338935). Metrizamide is used as an diagnostic aid (radiopaque medium).

安全信息

WGK Germany2

RTECSLZ6650000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2910 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4001323

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4001323

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - anticonvulsant
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   RADLAX Radiology.  (Radiological Soc. of North America, 20th & Northampton
   Sts., Easton, PA 18042) V.1-    1923-  Volume(issue)/page/year: 140,713,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 21763 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARASA5 Acta Radiologica, Supplementum.  (Acta Radiologica, POB 7449, S-10391
   Stockholm, Sweden) No.1-    1921-  Volume(issue)/page/year: 335,5,1973

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TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 54008 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   NIIHAO Nichidoku Iho.  Japanese-German Medical Reports.  (Nihon Scheringu
   K.K, Gakujutsubu, 6-64, Nishimiyahara, 2-chome, Yodogawa-ku, Osaka 532,
   Japan)  V.1-    1956-  Volume(issue)/page/year: 24,287,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11456 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   NIIHAO Nichidoku Iho.  Japanese-German Medical Reports.  (Nihon Scheringu
   K.K, Gakujutsubu, 6-64, Nishimiyahara, 2-chome, Yodogawa-ku, Osaka 532,
   Japan)  V.1-    1956-  Volume(issue)/page/year: 24,277,1979

TYPE OF TEST            : TDLo - Lowes

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 34369 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NIIHAO Nichidoku Iho.  Japanese-German Medical Reports.  (Nihon Scheringu
   K.K, Gakujutsubu, 6-64, Nishimiyahara, 2-chome, Yodogawa-ku, Osaka 532,
   Japan)  V.1-    1956-  Volume(issue)/page/year: 24,277,1979