CAS 306-07-0 MFCD00012492-N-Methyl-N-propargylbenzylamine Hydrochloride 帕吉林盐酸盐 TAO{mole}

N-Methyl-N-propargylbenzylamine Hydrochloride 帕吉林盐酸盐

CAS 306-07-0 MFCD00012492

化学结构图

SMILES: C#CCN(C)Cc1ccccc1.Cl

化学属性

Mol. Formula	C11H14ClN
Mol. Weight	196
Melting Point	160-163 °C(lit.)

别名和识别编码

Chemical Name	N-Methyl-N-propargylbenzylamine Hydrochloride
Synonym	N-甲基-N-丙炔基苄胺盐酸盐 Pargyline chloride USAF A-19120 N-Methyl-N-(2-propynyl)benzylamine hydrochloride Benzylmethylpropynylamine hydrochloride N-甲基-N-2-丙炔基苄胺盐酸盐 N-甲基-N-丙炔基苄胺盐酸盐优降宁盐酸盐 2-Propynylamine, N-benzyl-N-methyl-, hydrochloride MO 911 巴吉林盐酸盐,丙炔甲基苄胺,帕吉林,巴吉林 A 19120 N-Benzyl-N-methyl-2-propynylamine hydrochloride N-甲基-N-2-丙炔基苄胺盐酸盐优降宁 Pargyline hydrochloride Eudatin
CAS Number	306-07-0
PubChem Substance ID	9373
EC Number	206-175-1
Beilstein Registry Number	3699487
MDL Number	MFCD00012492
Chemical Name Translation	帕吉林盐酸盐
Wiswesser Line Notation	1UU2N1&1R &GH
LabNetwork Molecule ID	LN01289095
InChI	InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

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分类

Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epigenetics, Histone Lysine Demethylase Inhibitors, Histone Methylation Modulators, L to O, Molecular Biology, Monoamine Oxidase B, Monoamine oxidase inhibitor, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, P
{SNA} Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
{SNA} Bioactive Small Mol

产品应用

具有明显的降压作用，单胺氧化酶(MAO-B)选择性抑制剂。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

RTECSDP6650000

Precautionary statements

P301+P310

Signal word Danger

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Storage condition -20℃保存

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1500 ug/kg/D
TO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Nutritional

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 107,1068,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 680 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - body temperature increase
   Behavioral - changes in motor activity (specific assay)
   Biochemical - Neurotransmitters or modulators (putative) - catecholamine
   levels in CNS
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 107,1068,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 26,232,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 12 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JOENAK Journal of Endocrinology.  (Biochemical Soc. Book Depot, POB 32,
   Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1939-
   Volume(issue)/page/year: 27,147,1963

其他信息

有特异臭。易溶于水。水溶液不稳定，3.18％溶液为等渗溶液。