CAS 30516-87-1 MFCD00006536-3'-Azido-3'-deoxythymidine 3’-叠氮-3’-脱氧胸苷 TAO{mole}

3'-Azido-3'-deoxythymidine 3’-叠氮-3’-脱氧胸苷

CAS 30516-87-1 MFCD00006536

化学结构图

SMILES: CC1=CN([C@@H]2C[C@@H](N=[N+]=[N-])[C@H](CO)O2)C(=O)NC1=O |&1:4,6,10|

化学属性

Mol. Formula	C10
Mol. Weight	267
Melting Point	113-115
Stability	对光敏感，易吸潮

别名和识别编码

Chemical Name	3'-Azido-3'-deoxythymidine
CAS Number	30516-87-1
Alfabeta Name	AZIDOTHYMIDINEAZT ()
MDL Number	MFCD00006536
Synonym	1-(3-叠氮基-2 3'-Azido-3'-deoxythymidine 3-二脱氧-β-D-呋喃核糖基)胸腺嘧啶 3′-叠氮-3′-脱氧胸苷 3′-叠氮-3′-脱氧胸苷 AZT ZDV 叠氮胸苷齐多夫定 AZT AZT ZDV 叠氮胸苷齐多夫定 AZT;ZDV;齐多夫定;叠氮胸苷;1-(3-叠氮基-2,3-二脱氧-β-D-呋喃核糖基)胸腺嘧啶 Azidothymidine BW-A 509U Retrovir ZDV 叠氮胸苷齐多夫定
PubChem Substance ID	87559740
Beilstein Registry Number	3595791
Reaxys-RN	3595791
Merck Number	10123
Chemical Name Translation	3’-叠氮-3’-脱氧胸苷
InChIKey	HBOMLICNUCNMMY-XLPZGREQSA-N

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分类

{SNA} AIDS and Viral Research Reagents, AN-AZ, Bioactive Small Molecules, Biochemicals and Reagents, Cell Bi
{SNA} AIDS and Viral R
{SNA} AIDS and Viral Research Reagents, AN-AZ, Bioactive Small Molecule Alphabetical Index, Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Copper Click Chemistry, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Immune Cell Signaling and Blood, Immune System Regulation, Nucleoside/Nucleotide Azides/Alkynes, Organic Azides, R to Z, Reverse Transcriptase, AMV, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany3

Hazard Codes Xn

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H303 May be harmfully swallowed 吞食可能有害

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSXP2072000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Storage condition 储存温度 -20℃

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 434 mg/kg/38D-I
TOXIC EFFECTS :
   Blood - changes in cell count (unspecified)
   Blood - aplastic anemia
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   107,502,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Hu

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4804651

TYPE OF TEST            : LDLo - Lowes

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4857511

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #48575

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   49,5829,1989

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 600 mg/kg/3D (Continuous)
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   18,168,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 321,113,1994

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 170 mg/kg/2W (Intermittent)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issu

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 321,113,1994

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 321,113,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 27900 mg/kg
SEX/DURATION            : female 26 day(s) pre-mating  - 15 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   32,140,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4200 mg/kg
SEX/DURATION            : male 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 69 gm/kg
SEX/DURATION            : male 85 day(s) pre-mating
                          female 26 day(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   32,140,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 6500 mg/kg
SEX/DUR

其他信息

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