2-Chloro-5-(2-Phenyl-4-(Pyridin-4-Yl)-1H-Imidazol-5-Yl)Phenol 2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-5-基)苯酚
CAS 303727-31-3 MFCD12828750
化学结构图
SMILES: Oc1cc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)ccc1Cl
化学属性
| Mol. Formula | C20H14ClN3O |
|---|---|
| Mol. Weight | 347.8 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 2-Chloro-5-(2-Phenyl-4-(Pyridin-4-Yl)-1H-Imidazol-5-Yl)Phenol |
|---|---|
| CAS Number | 303727-31-3 |
| Synonym | 2-Chloro-5-[2-phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol 4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-imidazole L779450; L-779450; L 779450; L779,450; L 779,450; L-779,450. |
| Chemical Name Translation | 2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-5-基)苯酚 |
| Formula | C20H14ClN3O |
| IUPAC Name | 2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol |
| InChIKey | WXJLXRNWMLWVFB-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24) |
| Canonical SMILES | OC1=CC(C2=C(C3=CC=NC=C3)NC(C4=CC=CC=C4)=N2)=CC=C1Cl |
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分类
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- L-779450 is a potent, selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM). L-779450 suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.
相关文献及参考
- Takle, A., et al.: Bioorg. Med. Chem. Lett., 16, 378 (2006),
- Zhu, T., et al.: Bioorg. Med. Chem. Lett., 18, 2346 (2008),
