N-(4-(2-Ethyl-4-(M-Tolyl)Thiazol-5-Yl)Pyridin-2-Yl)Benzamide N-(4-(2-乙基-4-(间甲基苯基)噻唑-5-基)吡啶-2-基)苯甲酰胺
CAS 303162-79-0 MFCD17012805
化学结构图
SMILES: CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1
化学属性
| Mol. Weight | 399.51 |
|---|---|
| Mol. Formula | C24H21N3OS |
| Appearance | Light to dark yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Synonym | N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide TAK715, TA 715, TAK715 |
|---|---|
| Chemical Name | N-(4-(2-Ethyl-4-(M-Tolyl)Thiazol-5-Yl)Pyridin-2-Yl)Benzamide |
| MDL Number | MFCD17012805 |
| PubChem Substance ID | 329825362 |
| CAS Number | 303162-79-0 |
| Chemical Name Translation | N-(4-(2-乙基-4-(间甲基苯基)噻唑-5-基)吡啶-2-基)苯甲酰胺 |
| Formula | C24H21N3OS |
| IUPAC Name | N-(4-(2-ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide |
| InChIKey | HEKAIDKUDLCBRU-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28) |
| Canonical SMILES | O=C(NC1=NC=CC(C2=C(C3=CC=CC(C)=C3)N=C(CC)S2)=C1)C4=CC=CC=C4 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Casein Kinase (CK), Kinase/Phosphatase Biology, MAPK-Activated Protein Kinase (MAPKAP Kinase), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- TAK-715 is a potent p38 MAPK inhibitor. which displays potent inhibitory activity (inhibition of p38alpha, IC50 = 7.1 nM; LPS-stimulated release of TNF-alpha from THP-1, IC50 = 48 nM; LPS-induced TNF-alpha production in mice, 87.6% inhibition at 10 mg/kg, po) and no inhibitory activity for major CYPs, including CYP3A4. TAK-715 was selected as a clinical candidate and is now under clinical investigation for the treatment of RA.
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
GHS Symbol
- P305+P351+P338
- R36 Irritating to eyes 刺激眼睛
- R22 Harmful if swallowed 吞咽有害
