CAS 299-84-3 MFCD00055245-Fenchlorphos 皮蝇磷 TAO{mole}

Fenchlorphos 皮蝇磷

CAS 299-84-3 MFCD00055245

化学结构图

SMILES: COP(=S)(OC)Oc1cc(Cl)c(Cl)cc1Cl

化学属性

Mol. Formula	C8H8Cl3O3PS
Mol. Weight	321.54
Flash Point	-18 °C
Solubility	难溶于水，易溶于多数有机溶剂。
Density	1.0

别名和识别编码

Chemical Name	Fenchlorphos
Synonym	0,O-二甲基-O-(2,4,5-三氯苯基)硫代磷酸酯 O,O- Blitex DOW ET-14 Dermafos Dermafosu Dermaphos Dimethyl (2,4,5-trichlorophenyl) phosphorothionate Dimethyl O-(2,4,5-trichlorophenyl) thiophosphate Dow E ENT 23,284 Etrolene Fenchlorfosu Fenchlorophos Fenclofos Gesektin K KORLAN(R) Korlan Moor Man's Medicated Rid-Ezy Moorman's Medicated Rid-Ezy Moorman's Medicated Rid-Ezy Nanchor Nankor O,O-DIMET O,O-DIMETHYL-O-[2,4,5-TRICHLOROPHENYL]-PHOSPHOROTHIOATE O,O-Dimethyl O-(2,4,5-trichlorophenyl) thiophosphate O,O-dimethyl O-2,4,5-trich O,O-dimethyl-O-(2,4,5-trichlorophenyl)-phosphor
MDL Number	MFCD00055245
PubChem Substance ID	9298
Beilstein Registry Number	1885571
CAS Number	299-84-3
EC Number	206-082-6
Chemical Name Translation	皮蝇磷
Merck Number	13,8337
Wiswesser Line Notation	GR BG DG EOPS&O1&O1
InChI	InChI=1S/C8H8Cl3O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3

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产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

安全信息

Hazard statements

H302+H312
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

RTECSTG0525000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P302+P352
P304+P340
P305+P351+P338
P308+P313
P309+P311
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P337+P313
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard Codes Xn,N,F Xn,N

WGK Germany3

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Signal word Warning

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S25 Avoid contact with eyes 避免眼睛接触；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；

Risk Statements

R11 Highly flammable 非常易燃
R38 Irritating to skin 刺激皮肤
R50/53
R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥

Storage condition APPROX 4°C

UN Number UN 1145 3/PG 2

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2823 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 129,699,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,965,1966

TYPE OF TEST

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 102,89,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   AVSCA7 Acta Veterinaria Scandinavica.  (Danske Dyrlargeforening, Alhambravej
   15, DK-1826 Copenhagen V, Denmark)  V.1-    1959- Volume(issue)/page/year:
   24,295,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Heal

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 30-50 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AVSCA7 Acta Veterinaria Scandinavica.  (Danske Dyrlargeforening, Alhambravej
   15, DK-1826 Copenhagen V, Denmark)  V.1-    1959- Volume(issue)/page/year:
   24,99,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 30-50 day(s) after conception
TOXIC EFFECTS :
   Reproductive -

其他信息

外观性质:白色结晶粉末或颗粒.
MOL 文件:299-84-3.mol
RTECS号:TG0525000
用途:皮蝇硫磷对多种害虫有很好的杀虫效果,兼具动物内吸和熏蒸作用。一般在驱虫上主要是利用动物内吸。由于蒸气压高，因此本品对卫生害虫，如家蝇很效，可以放在开口的容器内保存12-16周有效。同时因毒性低，可用于食品加工厂灭蝇，此外，使用本品熏蒸可有效防治粮食害虫。对农业害虫如麦杆蝇，防治效果与敌百虫相似，对小菜蛾的防治交果可达94.5%。
易溶于于丙酮，四氯化碳，乙醚，氯仿等，难溶于水，在中性和酸性介质中稳定，但在碱性介质中易水解失去杀虫活性
生产方法:由 2,4,5-三氯苯酚与O,O-二甲基硫代磷酰氯缩合而得。将2,4,5-三氯苯酚，25%氢氧化钠加入反应锅内，搅拌，加热至50-60℃，使其全部溶解。冷至45℃，滴加O，O，-二甲基硫代磷酰氯，滴完后在45℃搅拌10min。升温至65℃，维持20min。冷至40℃，加入10%氢氧化钠溶液。继续冷却，析出皮蝇硫磷结晶，在13.5-14.5℃时过滤。依次用水，0.75%（体积）盐酸溶液，水洗涤，得粗品。用乙醇重结晶，得白色成品，收率约95%。