CAS 298-83-9 MFCD00012159-2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2) 氯化硝基四氮唑兰 TAO{mole}

2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2) 氯化硝基四氮唑兰

CAS 298-83-9 MFCD00012159

化学结构图

SMILES: [Cl-].[Cl-].COC1C=C(C=CC=1[N+]1=NC(=NN1C1C=CC(=CC=1)[N+]([O-])=O)C1C=CC=CC=1)C1=CC(OC)=C(C=C1)[N+]1=NC(=NN1C1C=CC(=CC=1)[N+]([O-])=O)C1C=CC=CC=1

化学属性

Mol. Formula	C40H30Cl2N10O6
Mol. Weight	817.64
Density	1.422
Melting Point	-190 °C
Solubility	Soluble in methanol (50 g/L), water (10 mg/ml), 2-methoxyethanol (20 mg/ml), and ethanol (5 mg/ml).
Stability	对热,光和空气敏感

别名和识别编码

Chemical Name	2H-Tetrazolium, 2,2'-(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[3-(4-nitrophenyl)-5-phenyl-, chloride (1:2)
Synonym	Nitro blue tetrazolium chloride {LY} Nitro blue tetrazolium chloride {} {LY} Nitro blue tetrazolium chloride {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nitro blue tetrazolium chloride {} {} {} {} {} {} {} {} {} {} {}
CAS Number	298-83-9
PubChem Substance ID	9281
EC Number	206-067-4
Beilstein Registry Number	4115923
MDL Number	MFCD00012159
Reaxys-RN	3896823
Chemical Name Translation	氯化硝基四氮唑兰
LabNetwork Molecule ID	LN00194851
InChI	InChI=1S/C40H30N10O6.2ClH/c1-55-37-25-29(13-23-35(37)47-43-39(27-9-5-3-6-10-27)41-45(47)31-15-19-33(20-16-31)49(51)52)30-14-24-36(38(26-30)56-2)48-44-40(28-11-7-4-8-12-28)42-46(48)32-17-21-34(22-18-32)50(53)54;;/h3-26H,1-2H3;2*1H/q+2;;/p-2
Canonical SMILES	COC1=CC(C2=CC=C(N3N=C(C4=CC=CC=C4)N=[N+]3C5=CC=C([N+]([O-])=O)C=C5)C(OC)=C2)=CC=C1N6N=C(C7=CC=CC=C7)N=[N+]6C8=CC=C([N+]([O-])=O)C=C8.[Cl-].[Cl-]

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分类

{SNA} Alkaline Phosphatase Substrates for Western Blotting, Alphabetical Listing, Colorimetric, Core Bioreagents, Detection, Detection Substrates, Enzyme Substrates, Life Science Reagents for Western Blotting, Research Essentials, Stains and Dyes, Substrates, Tablets, Western Blotting, 生化试剂, 酶、抑制剂和底物
{SA} Alkaline Phosphatase,
{SNA} Alkaline Phosphatase,
{SNA} Cell Biology, Hematology Stains, Hematology and Histology
{SNA} Hematology Stains, Hematology and Histology, 细胞生物学
Alkaline Phosphatase, BCIP/NBT Substrate Systems, Biochemicals and Reagents,
{SNA} Hematology Stains, 细胞生物学, 血液学和

产品应用

脱氢酶和其它过氧化酶的底物。用于测定葡萄糖-6-磷酸脱氢酶（glucose-6-phosphate dehydrogenase）；也是凝血因子I（fibrinogen）的沉淀试剂。
也是碱性磷酸酶底物之一，在碱性磷酸酶的催化下生成不溶性的蓝色产物。常用于免疫组化(IHC)、免疫细胞化学(ICC)和蛋白印迹(WB)等实验。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害
H370 Causes damage to organs 导致器官损伤
H318 Causes serious eye damage 严重伤害眼睛

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard Codes T Xn

RTECSXF8045000

Signal word {} {} {TCI} Danger

Storage condition 2-8°C, sealed storage, away from moisture and light {LY} 2-8°C, sealed storage, away from moisture and light <0°C <;0 {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {}

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P332+P313
P305+P351+P338+P337+P313
P301+P312+P330
P337+P313
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P350

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R68/20/21/22
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

其他信息

溶于水，溶于甲醇。
p-Nitroblue Tetrazolium Chloride is an NADPH-diaphorase substrate that competitively inhibits NOS (nitric oxide synthase) (IC50 = 3-4 μM). p-Nitroblue Tetrazolium Chloride is a well-known scavenger of superoxide anions and is useful as a substrate for alkaline phosphatase, often in conjunction with BCIP.