CAS 298-81-7 MFCD00005009-8-Methoxypsoralen 8-甲氧基补骨脂素 TAO{mole}

8-Methoxypsoralen 8-甲氧基补骨脂素

CAS 298-81-7 MFCD00005009

化学结构图

SMILES: COC1C2OC=CC=2C=C2C=CC(=O)OC2=1

化学属性

Mol. Formula	C12H8O4
Mol. Weight	216.19
Melting Point	143-148°C
TSCA	Yes
Solubility	Soluble in acetone, ethanol (slight), acetic acid, and chloroform (50 mg/ml). Insoluble in water.
Density	1.368
Appearance	8-甲氧基补骨脂素(298-81-7)难溶于水。具有强烈的光敏活性，易被长效紫外线激活而产生光毒作用，能使皮肤DNA合成及细胞分裂受到抑制。能在白斑部位集结紫外线，加速黑色素的生成。
Stability	对光敏感
Boiling Point	414.8°C at 760 mmHg
Flash Point	204.7°C

别名和识别编码

Chemical Name	8-Methoxypsoralen
MDL Number	MFCD00005009
CAS Number	298-81-7
Synonym	Methoxsalen {LY} Methoxsalen {} {LY} Methoxsalen {} {} {LY} Methoxsalen {} {} {} {LY} Methoxsalen {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methoxsalen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number	206-066-9
Merck Number	5988
Beilstein Registry Number	19(1)711
PubChem Substance ID	87577878
Chemical Name Translation	8-甲氧基补骨脂素
Reaxys-RN	196453
Wiswesser Line Notation	T C566 DO LVOJ BO1
LabNetwork Molecule ID	LN00238920
InChI	InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
Canonical SMILES	O=C1OC(C(C=C1)=C2)=C(OC)C3=C2C=CO3

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品牌质保精细包装现货库存一流品牌服务

产品应用

A potent suicide inhibitor of cytochrome P-450.

安全信息

RTECSLV1400000

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护；
S20 When using do not eat or drink 使用时，不得进食，饮水；

Risk Statements

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P301+P330+P331
P305+P351+P338
P308+P311
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P342+P311
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Hazard Codes Xn

Packing GroupII

UN Number

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18025 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-359,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 158 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 2,309,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 423 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 2,309,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 505 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
   International Symposium, Paris, 1981," Cahn, J., et

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : In

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOS

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 505 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   48PRAW "Psoralens in Cosmetics and Dermatology, Proceedings of the
   International Symposium, Paris, 1981," Cahn, J.,

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 666 ug/plate
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-359,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-359,1989

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 umol/L
REFERENCE :
   BUCABS Bulletin du Cancer.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-
   1966-  Volume(issue)/page/year: 67,245,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 umol/L
REFERENCE :
   BUCABS Bulletin du Cancer.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-
   1966-  Volume(issue)/page/year: 67

TYPE OF TEST            : Sister chromatid exchange

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 33300 ug/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-359,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   PLMEAA Planta Medica.  (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart
   1, Fed. Rep. Ger.) V.1-    1953-  Volume(issue)/page/year: 42,333,1981

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB92-219666

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB92-219666

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB92-219666

其他信息

Sigma Aldrich:298-81-7(sigmaaldrich)
8-甲氧基补骨脂素价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 X0009 花椒毒素 Xanthotoxin 1G 422元 2014/06/02 X0009 花椒毒素 Xanthotoxin 100MG 117元 2010/06/21 214150050 8-甲氧基补骨脂素 8-Methoxypsoralen 99% 5 GR 1814元
用途二:治疗牛皮癣、白癫风。
TCI Shanghai:8-甲氧基补骨脂素 or 花椒毒素 Xanthotoxin,>;98.0%(GC)(298-81-7)
用途一:用于治疗牛皮癣、白癫风等疾病
MOL 文件:298-81-7.mol
图谱信息:8-甲氧基补骨脂素(298-81-7)核磁图( 1 HNMR) 8-甲氧基补骨脂素(298-81-7)红外图谱(IR1) 8-甲氧基补骨脂素(298-81-7)质谱(MS) 8-甲氧基补骨脂素(298-81-7)Raman光谱
F:10
Acros Organics:8-甲氧基补骨酯 8-Methoxypsoralen, 99%(298-81-7)
Alfa Aesar:8-甲氧基补骨脂素,99% 8-Methoxypsoralen, 99%(298-81-7)
MSDS 信息:Methoxsalen(298-81-7).msds