CAS 298-59-9 MFCD00058191-Methylphenidate hydrochloride [USP:JAN] 盐酸哌甲酯 TAO{mole}

Methylphenidate hydrochloride [USP:JAN] 盐酸哌甲酯

CAS 298-59-9 MFCD00058191

化学结构图

SMILES: Cl.COC(=O)C(C1CCCCN1)C1C=CC=CC=1

化学属性

Mol. Formula	C14H19NO2.ClH
Mol. Weight	269.80

别名和识别编码

Chemical Name	Methylphenidate hydrochloride [USP:JAN]
CAS Number	298-59-9
Synonym	methylphenidate hydrochloride methanolsolution Ritalin hydrochloride Centedrine meridilhydrochloride methylalpha-phenyl-2-piperidineacetatehydrochloride 盐酸哌甲酯 ######## METHYLPHENIDATEHYDROCHLORIDE,USP Meridil hydrochloride Methyl phenyl(piperidin-2-yl)acetate hydrochloride Methyl alpha-phenyl-2-piperidineacetate hydrochloride METHYLPHENIDATE HYDROCHLORIDE--DEASCHED 2-Piperidineacetic acid, a-phenyl-, methyl ester, hydrochloride (6CI, 8CI, 9CI) METHYLPHENIDATE HCL 2-piperidineaceticacid,alpha-phenyl-,methylester,hydrochloride Concerta Centedrin threo-methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride Ciba 4311b Metadate CD RITALIN HYDROCHLORIDE Methylphenidate hydrochloride ALPHA-苯基-2-哌啶乙酸甲酯盐酸盐 a-Phenyl-2-piperidineacetic Acid Methyl Ester Hydrochloride Methyl a-phenyl-2-piperidineacetate hydrochloride METHYLPHENIDATE HYDROCHLORIDE METHYLPHENIDATE HYDROCHLORIDE(RITALIN HYDROCHLORIDE) NSC 169868
MDL Number	MFCD00058191
PubChem Substance ID	9280
EC Number	206-065-3
Chemical Name Translation	盐酸哌甲酯
Wiswesser Line Notation	T6MTJ BYR&VO1 &GH
InChIKey	JUMYIBMBTDDLNG-UHFFFAOYSA-N
InChI	InChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H

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产品应用

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安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。

Hazard statements

H302 Harmful if swallowed 吞食有害
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

RTECSTM3850000

Signal word Danger

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R42 May cause sensitisation by inhalation 吸入会产生过敏反应
R22 Harmful if swallowed 吞咽有害

Packing GroupIII

Hazard Class6.1(b)

UN Number 3249

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18250 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-439,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 241,182,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 96500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3749765

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KLWOAZ Klinische Wochenscrift.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1922-  Volume(issue)/page/year:
   32,445,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 702 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 500 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   6),4,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 gm/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

其他信息

Sigma Aldrich:298-59-9(sigmaaldrich)
MOL 文件:298-59-9.mol