Norfludiazepam 7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮

CAS 2886-65-9 MFCD00083443

化学结构图

2886-65-9
SMILES: O=C1CN=C(c2ccccc2F)c2cc(Cl)ccc2N1

化学属性

Mol. FormulaC15H10ClFN2O
Mol. Weight288.72
Melting Point204-206°C

别名和识别编码

Chemical Name7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS Number2886-65-9
Synonym ######## 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-2h-4-benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro- 5-(2-FLUOROPHENYL)-7-CHLORO-1,4-BENZODIAZEPIN-2-ONE 5-(2-Fluorophenyl)-7-chloro-1,4-benzodiazepin-2-one 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-1,4-BENZODIAZEPIN-2-ONE 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one 7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮 7-氯-5-(2-氟苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮
MDL NumberMFCD00083443
PubChem Substance ID4540
EC Number220-748-3
Chemical Name Translation7-氯-5-(2-氟苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮
Wiswesser Line NotationT67 GMV JN IHJ CG KR BF
Beilstein Registry Number0754061
LabNetwork Molecule IDLN00196187
InChIInChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, N, NJ - NZ, Neurobiology, Neuroscience, Pharmacologicals

产品应用

  • The major human metabolite of Flurazepam.

相关文献及参考

  • Ochs, H.R.

安全信息

RTECSDF2370100
WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Restrict 精神药品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   26RAAN "Benzodinzenines,"  Garattini, S., et al.,  New York, Raven Press,
   1973  Volume(issue)/page/year: -,46,1973

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • Sigma Aldrich:2886-65-9(sigmaaldrich)
  • MOL 文件:2886-65-9.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. N - Bioactive Small Molecules

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