SB-408124 1-(6,8-二氟-2-甲基喹啉-4-基)-3-(4-(二甲基氨基)苯基)脲
CAS 288150-92-5 MFCD06411575
化学结构图
SMILES: CC1C=C(NC(=O)NC2C=CC(=CC=2)N(C)C)C2C=C(F)C=C(F)C=2N=1
化学属性
| Mol. Formula | C19H18F2N4O |
|---|---|
| Mol. Weight | 356.37 |
别名和识别编码
| Chemical Name | SB-408124 |
|---|---|
| Synonym | N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea SB-408124 |
| MDL Number | MFCD06411575 |
| PubChem Substance ID | 329824523 |
| Chemical Name Translation | 1-(6,8-二氟-2-甲基喹啉-4-基)-3-(4-(二甲基氨基)苯基)脲 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, Hormones, Obesity Research, Orexin, S, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, GlaxoSmithKline, Hormones, Obesity Research, Orexin, S
相关文献及参考
- [2]. Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463(4):531-536.
- [1]. Langmead CJ, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141(2):340-346.
- [1]. Langmead CJ, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141(2):340-346.
- [2]. Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463(4):531-536.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
