6-(1,3-Dioxo-1H-Benzo[De]Isoquinolin-2(3H)-Yl)-N-Hydroxyhexanamide 6-(1,3-二氧代-1H-苯并[de]异喹啉-2(3H)-基)-N-羟基己酰胺
CAS 287383-59-9 MFCD00386477
化学结构图
SMILES: ONC(=O)CCCCCN1C(=O)C2C=CC=C3C=CC=C(C3=2)C1=O
化学属性
| Mol. Formula | C18H18N2O4 |
|---|---|
| Mol. Weight | 326 |
别名和识别编码
| Chemical Name | 6-(1,3-Dioxo-1H-Benzo[De]Isoquinolin-2(3H)-Yl)-N-Hydroxyhexanamide |
|---|---|
| CAS Number | 287383-59-9 |
| Synonym | 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide |
| MDL Number | MFCD00386477 |
| Chemical Name Translation | 6-(1,3-二氧代-1H-苯并[de]异喹啉-2(3H)-基)-N-羟基己酰胺 |
| PubChem Substance ID | 329824590 |
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分类
- {SNA} Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
- {SNA} Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research,
- {SNA} Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, D to K, DNA-RNA Transcription Regulators, Enzyme Inhibitors,
产品应用
- Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGF?/Smad4) in both stable and transient receptor assays in a concentr
相关文献及参考
- Won, J., et al.: Proc. Natl. Acad. Sci., 101, 11328 (2004),
- Su, G.H., et al.: Cancer Res., 60, 3137 (2000),
- Hauke, J., et al., Survival Motor Neuron Gene 2 Silencing By DNA Methylation Correlates With Spinal Muscular Atrophy Disease Severity And Can Be Bypassed By Histone Deacetylase Inhibition. Hum. Mol. Genet. 18 , 304-17, (2009) 摘要
- Su, G., et. al., , A Novel Histone Deacetylase Inhibitor Identified by High-Throughput Transcriptional Screening of a Compound Library. Cancer Res. 60 , 3137-3142, (2000) 摘要
