(((2S)-5-guanidino-1-(((2S)-1-((5-guanidino-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)phenylalanine dihydrochloride 抑肽素
CAS 26305-03-3 MFCD00060740
化学结构图
SMILES: C[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)CC(O)=O
化学属性
| Mol. Formula | C34H63N5O9 |
|---|---|
| Mol. Weight | 686 |
| Melting Point | 233 |
别名和识别编码
| Chemical Name | (((2S)-5-guanidino-1-(((2S)-1-((5-guanidino-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)phenylalanine dihydrochloride |
|---|---|
| MDL Number | MFCD00060740 |
| PubChem Substance ID | 24898519 |
| Beilstein Registry Number | 2201362 |
| CAS Number | 26305-03-3 |
| EC Number | 247-600-0 |
| Synonym | Pepstatin 胃酶抑素 A |
| Chemical Name Translation | 抑肽素 |
| Wiswesser Line Notation | QV1YQY1Y1&1&MVY1&MV1YQY1Y1&1&MVYY1&1&MVYY1&1&MV1Y1&1 |
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分类
- {SNA} Core Bioreagents, Enzyme Inhibitors, Individual Protease Inhibitors, Miscellaneous Peptides, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitors, Research Essentials, 分子生物学, 天然蛋白质样品制备, 生化试剂, 细胞信号转导和神经科学,
相关文献及参考
- [2]. Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6612-6.
- Berga-Bolaños, R., et al., NFAT5 Regulates T Lymphocyte Homeostasis And CD24-dependent T Cell Expansion Under Pathologic Hypernatremia. J. Immunol. 185 , 6624-35, (2010) 摘要
- Chen, D., et al., Identifying catalytic residues in CPAF, a Chlamydia-secreted protease. Arch. Biochem. Biophys. 485 , 16-23, (2009) 摘要
- Deutscher, M.P. Meth. Enzymol. 182 , 83-89, (1990)
- FT-IR 2 (1), 1336:A / RegBook 1 (1), 921:E / Sax 6 , 2143 / Structure Index 1 , 143:D:2
- Gegenheimer, P. Meth. Enzymol. 182 , 174-193, (1990)
- Kania, K., et al., Urinary Proteases Degrade Albumin: Implications For Measurement Of Albuminuria In Stored Samples. Ann. Clin. Biochem. 47 , 151-7, (2010) 摘要
- Li, X., et al., Increased Expression Of Cathepsins And Obesity-induced Proinflammatory
安全信息
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 6,57,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 23,259,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 23,259,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1090 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year:
TYPE OF TEST
