LFM-A13 (Z)-2-氰基-N-(2,5-二溴苯基)-3-羟基-2-丁烯酰胺
CAS 244240-24-2 MFCD09878279
化学结构图
SMILES: C/C(O)=C(\C#N)C(=O)Nc1cc(Br)ccc1Br
化学属性
| Mol. Weight | 360.0 |
|---|---|
| Mol. Formula | C11H8Br2N2O2 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Synonym | α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide LFM A13; LFM-A13; LFM A13 α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide |
|---|---|
| MDL Number | MFCD09878279 |
| CAS Number | 244240-24-2 |
| PubChem Substance ID | 329817646 |
| Chemical Name | LFM-A13 |
| Chemical Name Translation | (Z)-2-氰基-N-(2,5-二溴苯基)-3-羟基-2-丁烯酰胺 |
| Formula | C11H8Br2N2O2 |
| IUPAC Name | 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide |
| InChIKey | UVSVTDVJQAJIFG-VURMDHGXSA-N |
| InChI | InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6- |
| Canonical SMILES | C/C(O)=C(C#N)/C(NC1=CC(Br)=CC=C1Br)=O |
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分类
- Bioactive Small Molecules, Bruton′s tyrosine kinase (BTK), Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, L, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, Bruton's tyrosine kinase (BTK), Kinase/Phosphatase Biology, L, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). LFM-A13 may be useful as a new class of chemosensitizing and apoptosis-promoting antileukemic agents for treatment of patients with chemotherapy-resistant B-lineage leukemias or lymphomas.
相关文献及参考
- Mahajan, S., et al., Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. Vitamin E: A Comprehensive Treatise 274 , 9587, (1999)
- Zemans, R.L., et al., Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation. Cell. Immunol. 258 , 90-97, (2009) 摘要
- Jongstra-Bilen, J., et al., Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis. J. Immunol. 181 , 288-298, (2008) 摘要
- Mahajan, S., et al., ational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide]. J. Biol. Chem. 1999 274 , 9587-9599
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
