Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) disodium salt 地塞米松磷酸钠

CAS 2392-39-4 MFCD00079105

化学结构图

2392-39-4
SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]

化学属性

Mol. FormulaC22H28FNa2O8P·xH2O
Mol. Weight516.41(as Anhydrous)
Melting Point233-240°
TSCAYes
Density1.32
SolubilityH2O: 50 mg/mL, clear, faintly yellow

别名和识别编码

Chemical NamePregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) disodium salt
CAS Number2392-39-4
MDL NumberMFCD00079105
Beilstein Registry Number6473066
EC Number219-243-0
PubChem Substance ID24893369
Synonym DEXAMETHASON SODIUM PHOSPHATE Disodium dexamethasone phosphate DEXAMETHASONE PHOSPHATE SODIUM soldesam disodiumsalt,(11beta,16alpha)-y) dexadreson Dexamethasone sodium phosphate decadronphosphate Sodium dexamethasone phosphate disodiumdexamethasonephosphate Dexagro solu-decadron DEXAMETHASONE 21-PHOSPHATE DISODIUM SALT 16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-磷酸酯二钠盐 Dexamethasone disodium phosphate Soldesam Dexadreson pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonoox Decadron phosphate DEXAMETHASONE SODIUM PHOSPHATE 9-FLUORO-11 BETA,17 ALPHA,21-TRIHYDROXY-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-(DIHYDROGENPHOSPHATE)DIS 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT Dexacort 21-磷酸地塞米松, Megacort dexamethasonedisodiumphosphate 21-磷酸地塞米松二钠盐 Dexamethasone 21-phosphate disodium salt sodiumdexamethasonephosphate DEXAMETHASONE PHOSPHATE DISODIUM SALT Solu-Decadron dexagro megacort Turbinaire 地塞米松磷酸钠,16alpha-甲基-11beta,17alpha,21-三羟基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-磷酸酯二钠盐 Spersadox dexamethasone 21-(disodium phosphate) 9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt spersadox 地塞米松磷酸钠
Merck Number2943
Chemical Name Translation地塞米松磷酸钠
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OPWO FQ G1 &-NA-2
Reaxys-RN6473066
LabNetwork Molecule IDLN00200802
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分类

  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Ana
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D-DIF,
  • {SNA} Biochemicals and Reagents, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Steroids (C21) and Derivatives, Sterol Lipids, 细胞信号转导和神经科学, 细胞生物学, 脂类
  • {SNA} Biochemicals and Reagents,
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, D-DIF, Immune Cell Signaling

产品应用

  • 一种抗激动的促糖皮质激素，也是一种前体药物可在体内被转化成地塞米松，刺激谷胺酸盐吸收进大脑皮层。
  • 临床上用作肾上腺皮质激素类药，抗炎、抗毒、抗过敏。

相关文献及参考

  • [2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11.
  • [3]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56.
  • [4]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9.
  • Merck: 14,2943
  • [1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Enviro
  • [1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312+P330
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
RTECSTU4056000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R22 Harmful if swallowed 吞咽有害
Storage condition 0-10°C 2-8°C 储存温度 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 357 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - peritonitis
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 10,268,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 7,90,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 932 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,785,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 7,90,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 1500 ug/kg/3D-I
TOXIC EFFECTS :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 8 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ANIFAC Annales de Chirurgie Infantile.  (Paris, France)  V.1-    1960(?)-
   Volume(issue)/page/year: 3,73,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - horse, donkey
DOSE                    : 1304 ug/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JRFSAR Journal of Reproduction and Fertility, Supplement.  (Biochemical Soc.
   Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) No.1-   
   1966-  Volume(issue)/page/year: 32,247,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 8 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   ANIFAC Annales de Chirurgie Infantile.  (Paris, France)  V.1-    1

TYPE OF TEST            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 12800 ug/kg
SEX/DURATION            : female 11-14

其他信息

  • F:3-10
  • Sigma Aldrich:2392-39-4(sigmaaldrich)
  • 用途二:一种抗激动的促糖皮质激素，也是一种前体药物可在体内被转化成地塞米松，刺激谷胺酸盐吸收进大脑皮层。临床上用作肾上腺皮质激素类药，抗炎、抗毒、抗过敏。
  • 用途一:肾上腺皮质激素类药，抗炎、抗毒、抗过敏。
  • color:white to off-white
  • MOL 文件:2392-39-4.mol

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  5. Steroids (C21) and Derivatives - Sterol Lipids
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  5. Steroids (C21) and Derivatives - Sterol Lipids
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. Immunomodulators and Antibiotics - Immune System Regulation
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)

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