Alsterpaullone 7,12-二氢-9-硝基吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮
CAS 237430-03-4 MFCD02683579
化学结构图
SMILES: [O-][N+](=O)C1C=CC2NC3=C(CC(=O)NC4C=CC=CC=43)C=2C=1
化学属性
| Mol. Formula | C16H11N3O3 |
|---|---|
| Mol. Weight | 293.28 |
别名和识别编码
| Chemical Name | Alsterpaullone |
|---|---|
| Synonym | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one Alsterpaullone |
| CAS Number | 237430-03-4 |
| PubChem Substance ID | 24890918 |
| MDL Number | MFCD02683579 |
| Chemical Name Translation | 7,12-二氢-9-硝基吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮 |
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分类
- {SNA} A to C, A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclin Dependant Kinase I, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} A to C, A-AM, Bioactive Small Molecule Alphabetical Index, Cyclin Dependant Kinase I, Cyclin-Dependent Kinase (CDK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threon
相关文献及参考
- Schultz, C., et al., Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity . J. Med. Chem. 42 , 2909, (1999) 摘要
- Trevino, M., et al., Induction of canonical Wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella vectensis Dev. Dyn. 240 , 2673-9, (2011)
- Kalinichev, M. and Dawson, L.A., Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania Int. J. Neuropsychopharmacol. 14 , 1051-67, (2011)
- Takadera, T., et al., Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells Neurotox. Res. 21 , 309-16, (2012)
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
