CAS 23564-05-8 MFCD00055294-Thiophanate-Methyl 甲基托布津 TAO{mole}

Thiophanate-Methyl 甲基托布津

CAS 23564-05-8 MFCD00055294

化学结构图

SMILES: COC(=O)NC(=S)NC1C=CC=CC=1NC(=S)NC(=O)OC

化学属性

Mol. Formula	C12H14N4O4S2
Mol. Weight	342.42
Melting Point	172 ºC
Solubility	<0.1 G/100 ML AT 20 ºC

别名和识别编码

Chemical Name	Thiophanate-Methyl
CAS Number	23564-05-8
Synonym	Dimethyl ((1,2-phenylene)bis-(iminocarbonothioyl))bis(carbamate) Topsin turf and ornamentals Carbamic acid, (1,2-phenylenebis(iminocarbonothioyl))bis-, dimethyl ester Topsin WP methyl 1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene Sipcaplant ######## Enovit methyl Methyl topsin Enovit M Trevin BAS 32500F Fungo 50 Cycosin Methylthiofanate Metoben Tiofanate metile Fungo Cercobin methyl Sipcavit Topsin M Thiophanate methyl PELT-44 Easout Enovit Super Mildothane Cercobin M Caligran Dimethyl-4,4'-o-phenylene-bis-(3-thioallophanate) 1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene; Dimethyl (1,2-phenylenebis(iminocarbonothioyl))bis(carbamate) 1,2-Bis(methoxycarbonylthioureido)benzene Fungitox TD 1771 甲基硫菌灵 Topsin NF-44 Sipcasan Ditek Thiophanate M o-Bis(3-methoxycarbonyl-2-thioureido)benzene PELT 14 Neotopsin Methyl thiophanate Frumidor
MDL Number	MFCD00055294
PubChem Substance ID	24869253
Beilstein Registry Number	0937942
EC Number	245-740-7
Chemical Name Translation	甲基托布津
Wiswesser Line Notation	1OVMYUS&MR BMYUS&MVO1

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产品应用

Thiophanate-Methyl is a systematic fungicide of the thiophanate class. Thiophanate-Methyl is commonly used in agriculture to protect against powdery mildew, rot and other fungal diseases in fruits, ve

安全信息

RTECSBA3675000

GHS Symbol

Precautionary statements

P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H332 Harmful if inhaled 吸入有害
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H317 May cause an allergic skin reaction 可能导致皮肤过敏

Hazard Codes Xn;N Xn,N

WGK Germany2

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Signal word Warning

Safety Statements

S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R20 Harmful by inhalation 吸入有害
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R50/53

UN Number 3077

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - olfactory nerve change
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,606,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6640 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - olfactory nerve change
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,606,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1140 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - olfactory nerve change
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,606,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5 ppm
REFERENCE :
   RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione
   Umana.  Review of Science and Technology of Food and Human Nutrition.
   (Bologna, Italy)  V.5-6, 1975-76.  Discontinued.  Volume(issue)/page/year:
   6,161,1976

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 300,15,1993

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 14 umol/L
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 31,81,1979

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 394,29,1997

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 300,15,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 960 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   30,129,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 15 gm/kg
SEX/DURATION            : female 1-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   24,206,1973