CAS 23360-92-1 MFCD01716248-Vinleurosine TAO{mole}

Vinleurosine

CAS 23360-92-1 MFCD01716248

化学结构图

SMILES: CN1[C@H]2[C@](O)([C@H](OC(C)=O)[C@]3(CC)C=CCN4CC[C@]2([C@H]34)C2C=C(C(=CC1=2)OC)[C@]1(C[C@H]2C[C@]3(CC)O[C@@H]3N(C2)CCC2C3C=CC=CC=3NC1=2)C(=O)OC)C(=O)OC

化学属性

Mol. Formula	C46H56N4O9
Mol. Weight	809.06
Melting Point	202-205 ºC
Density	1.39

别名和识别编码

Chemical Name	Leurosine
Synonym	Vinleurosine Amotin Leurosine; (3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine NSC-528004 Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'-alpha,4'-alpha)-
CAS Number	23360-92-1
Beilstein Registry Number	0079636

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安全信息

RTECSOH6370000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   EKSODD Eksperimental'naya Onkologiya.  Experimental Oncology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Mosow, USSR)  V.1-    1979-
   Volume(issue)/page/year: 9(5),76,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 18,667,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15200 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(iss

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   EKSODD Eksperimental'naya Onkologiya.  Experimental Oncology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Mosow, USSR)  V.1-    1979-
   Volume(issue)/page/year: 9(5),76,1987