CAS 224-42-0 MFCD00055947-Dibenz(a,j)acridine 二苯并[a,j]吖啶 TAO{mole}

Dibenz(a,j)acridine 二苯并[a,j]吖啶

CAS 224-42-0 MFCD00055947

化学结构图

SMILES: c1ccc2c(c1)ccc1nc3ccc4ccccc4c3cc12

化学属性

Mol. Formula	C21H13N
Mol. Weight	279.33
Melting Point	218-220 °C
Boiling Point	412.11 °C at 760 mmHg

别名和识别编码

Chemical Name	Dibenz[a,j]acridine
CAS Number	224-42-0
Synonym	Dibenzo[a,j]acridine dibenz(a,h)acridine dibenz(a,j)acridine dibenzacridine {} {} {LY} Dibenzo[a,j]acridine {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dibenzo[a,j]acridine {} {} {} {} {} {}
MDL Number	MFCD00055947
PubChem Substance ID	9177
Beilstein Registry Number	0018508
Chemical Name Translation	二苯并[a,j]吖啶
Wiswesser Line Notation	T E6 D6 B666 NNJ
LabNetwork Molecule ID	LN00307588
InChI	InChI=1S/C21H13N/c1-3-7-16-14(5-1)9-11-20-18(16)13-19-17-8-4-2-6-15(17)10-12-21(19)22-20/h1-13H
Canonical SMILES	C1=CC=C2C(=C1)C=CC3=NC4=C(C=C23)C5=CC=CC=C5C=C4

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产品应用

A heterocyclic aromatic compound with potent mutagenic and carcinogenic properties.

安全信息

RTECSHN1050000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P318
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H351 Suspected of causing cancer 怀疑致癌

WGK Germany3

Signal word Warning

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Hazard Codes Xn

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Storage condition room temp

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   1,225,1940

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg/29W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   PRLBA4 Proceedings of the Royal Society of London, Series B: Biological
   Sciences.  (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK) V.76- 
     1905-  Volume(issue)/page/year: 117,318,1935

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 590 mg/kg/25W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer.  (Paris,
   France)  V.1-52, 1908-65. For publisher information, see BUCABS.
   Volume(issue)/page/year: 42,186,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 99 mg/kg/99W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by R

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   PNCCA2 Proceedings, National Cancer Conference.  (Philadelphia, PA)  V.1-7,
   1949-72.  For publisher information, see CANCAR.  Volume(issue)/page/year:
   5,39,1965

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,532,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 4 ug/plate
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   26,109,1995

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 5 mg/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   51,799,1973

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 20 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2520 mg/kg
SEX/DURATION            : female 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   DABSAQ Dissertation Abstracts B: The Sciences and Engineering.  (Ann Arbor,
   MI)  V.27-29, 1966-69. For publisher information, see DABBBA.
   Volume(issue)/page/year: 29,4777,1969