CAS 22204-53-1 MFCD00010500-(S)-Naproxen 萘普生 TAO{mole}

(S)-Naproxen 萘普生

CAS 22204-53-1 MFCD00010500

化学结构图

SMILES: COc1ccc2cc([C@@H](C)C(=O)O)ccc2c1

化学属性

Mol. Formula	C14
Mol. Weight	230
Melting Point	155.0 to 158.0 deg-C
TSCA	No

别名和识别编码

Chemical Name	(S)-Naproxen
CAS Number	22204-53-1
Alfabeta Name	METHOXYNAPHTHALENYLPROPANOICACID S262(())-----
MDL Number	MFCD00063744
Synonym	Naproxen S)-(+)-6-Methoxy--methyl-2-naphthaleneacetic acid; (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid; (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic aci (S)-(+)-6-甲氧基-α-甲基-2-萘乙酸 ######## Equiproxen CG 3117 (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid Naxen Proxen (S)-(+)-2-(6-甲氧基-2-萘基)丙酸 (+)-2-(6-Methoxy-2-naphthyl)-propionic a 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (+)- Naixan Floginax RS-3540 d-2-(6-Methoxy-2-naphthyl)propionic acid (+)-2-(Methoxy-2-naphthyl)-propionsaeure (S)-(+)-6-甲氧基-α-甲基-2-萘乙酸 (S)-(+)-2-(6-甲氧基-2-萘基)丙酸萘普生 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, (S)- (S)-(+)-6-甲氧基-α-甲基-2-萘乙酸 (S)-(+)-2-(6-甲氧基-2-萘基)丙酸萘普生 Naprosine
EC Number	244-838-7
Merck Number	6417
Beilstein Registry Number	3591067
PubChem Substance ID	87572993
Chemical Name Translation	萘普生
Reaxys-RN	3591067
Wiswesser Line Notation	L66J CY1&VQ HO1
LabNetwork Molecule ID	LN00177541

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产品应用

An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.

安全信息

Warnings IRRITANT

RTECSUF5275000

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Packing GroupIII

UN Number 2811

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

WGK Germany3

GHS Symbol

Hazard statements

H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Precautionary statements

P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P501 Dispose of contents/container to..… 处理内容物/容器.....
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P332+P313
P301+P310
P302+P350
P337+P313
P308+P313
P302+P352+P332+P313+P362+P364
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P201 Obtain special instructions before use. 使用前获取专门指示。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P405 Store locked up. 上锁保管。
P305+P351+P338
P302+P352
P305+P351+P338+P337+P313
P301+P310+P330

Signal word

Hazard Codes Xn

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3429 mg/kg/35W-I
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 68,766,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 435 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 179,114,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 mg/kg/7D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,281,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   119,600,198

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 120 ppm
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,288,1975

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 60 ppm
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 25,288,1975

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 393,123,1997

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 393,123,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JCGBDF Journal of Craniofacial Genetics and Developmental Biology.  (Alan R.
   Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1980-
   Volume(issue)/page/year: 10,83,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 20 mg/kg
SEX/DURATION            : female 30 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - respiratory system
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   ADCHAK Archives of Disease in Childhood.  (British Medical Journal, POB
   560B, Kennebunkport, ME 04046)  V.1-    1926-  Volume(issue)/page/year:
   54,942,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 20 mg/kg
SEX/DURATION            : female 30 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - Apgar score (human only)
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   ADCHAK Archives of Disease in Childhood.  (British Medical Journal, POB
   560B, Kennebunkport, ME 04046)  V.1-    1926-  Volume(issue)/page/year:
   54,942,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE