CAS 21679-14-1 MFCD00132942-2-Fluoroadenine-9-β-D-Arabinofuranoside 氟达拉宾 TAO{mole}

2-Fluoroadenine-9-β-D-Arabinofuranoside 氟达拉宾

CAS 21679-14-1 MFCD00132942

化学结构图

SMILES: NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |&1:11,13,16,18|

化学属性

Mol. Formula	C10H12FN5O4
Mol. Weight	285
TSCA	No

别名和识别编码

Chemical Name	2-Fluoroadenine-9-β-D-Arabinofuranoside
CAS Number	21679-14-1
Alfabeta Name	AMINOFLUOROPURINYLHYDROXYMETHYLTETRAHYDROFURANDIOL RSSRH234526299534((()))-------------,,,,
MDL Number	MFCD00132942
Synonym	2-Fluoro-9-?-D-arabinofuranosyladenine 2-Fluoroadenine Arabinoside 2-Fluoroadenine-9-β-D-arabinofuranoside 9-?-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine 9-bata-D-Arabinofuranosyl-2-fluoroadenine; 2-Fluoroadenine-9-bata-D-arabinofuranoside 9-beta-D-Arabinofuranosyl-2-fluoroadenine 9-β-D-Arabinofuranosyl-2-fluoroadenine F-ara-A Fludarabine des-phosphate F-Ara-A Fludarabine NSC 118218 NSC 118218H
Beilstein Registry Number	1225932
EC Number	244-525-5
PubChem Substance ID	24894830
Merck Number	14,4126
Chemical Name Translation	氟达拉宾
Wiswesser Line Notation	T56 BN DN FN HNJ GF IZ D- BT5OTJ CQ DQ E1Q

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产品应用

Used as an antineoplastic.

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSAU6207000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R39 Danger of very serious irreversible effects 有非常严重的不可挽回的作用的危险

Hazard Codes Xn

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,2587,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 210,291,1989

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 41 mg/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,2587,1982

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1500 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1405,1980

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。