SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively). SU5402
CAS 215543-92-3 MFCD08235144
化学结构图
SMILES: Cc1c[nH]c(/C=C2\C(=O)Nc3ccccc32)c1CCC(=O)O
化学属性
| Mol. Formula | C17H16N2O3 |
|---|---|
| Mol. Weight | 296.32054 |
| Appearance | Orange solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively). |
|---|---|
| CAS Number | 215543-92-3 |
| Synonym | 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl- 3-((3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene)-2-inolinone 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid PF-02969207 PNU-0290908 PF-02969207 PNU-0290908 SU 5402 SU-5402 SU5402 SU5402; SU-5402; SU 5402. Su-5402 |
| MDL Number | MFCD08235144 |
| PubChem Substance ID | 5289418 |
| Chemical Name Translation | SU5402 |
| InChI | InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8- |
| Formula | C17H16N2O3 |
| IUPAC Name | (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid. |
| InChIKey | JNDVEAXZWJIOKB-JYRVWZFOSA-N |
| Canonical SMILES | O=C(O)CCC1=C(/C=C2C(NC3=C\2C=CC=C3)=O)NC=C1C |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, FGF Receptors, Fibroblast Growth Factor Receptor (FGFR), Fibroblast Growth Factors (FGF), Kinase/Phosphatase Biology, New Products,
- Inhibitors
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines and Growth Factors,
产品应用
- SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).
相关文献及参考
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