CAS 2152-44-5 MFCD00867446-Betamethasone 17-Valerate 倍他米松-17-戊酸酯 TAO{mole}

Betamethasone 17-Valerate 倍他米松-17-戊酸酯

CAS 2152-44-5 MFCD00867446

化学结构图

SMILES: CCCCC(=O)O[C@]1(C(=O)CO)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

化学属性

Mol. Formula	C27H37FO6
Mol. Weight	476.64
Appearance	倍他米松戊酸酯(2152-44-5)为白色晶体或粉末，比旋光度+75°~+82°
Solubility	50 mg plus 1.0 mL MeOH:CHCl3 (1:1)

别名和识别编码

Chemical Name	Betamethasone 17-Valerate
CAS Number	2152-44-5
Synonym	倍他米松 17-戊酸酯 BEDERMIN 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione-17-valerate 17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione-9-fluoro-11-bet 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17-VALERATE betnovateat Betamethasonevalerateester 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE Betamethasone 17-valerate 9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮；17-戊酸盐 9α-氟-16β-甲基氢化泼尼松；17-戊酸盐倍他米松戊酸盐倍他米松戊酸酯 BETAMETHASONE 17ALPHA-VALERATE Betnovate 17-valerate Betnovateat 1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate ########
MDL Number	MFCD00867446
PubChem Substance ID	16533
Beilstein Registry Number	4240001
EC Number	218-439-3
Chemical Name Translation	倍他米松-17-戊酸酯
Merck Number	13,1183
Wiswesser Line Notation	L E5 B666 OV AHTTT&J A BF CQ E FV1Q FOV4 G -A&B-B&ACEFG
LabNetwork Molecule ID	LN01273645
InChI	InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

安全信息

RTECSTU3835000

WGK Germany2

Hazard Codes Xn

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

Risk Statements

R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险

UN Number UN 2811 6.1/PG 3 2811

Storage condition storage temp. 2-8°C 2-8°C

GHS Symbol

Precautionary statements

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 496 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SKIZAB Shikoku Igaku Zasshi.  Shikoku Medical Journal.  (Tokushima Igakkai,
   Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan)  V.1- 1950- 
   Volume(issue)/page/year: 29,153,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,2102,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4067 mg/kg
TOXIC EFFECTS :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4500 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 28,687,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 28,687,1984

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 19800 ug/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   YACHDS Yakuri to Chiryo.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3300 ug/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YKRYAH Yakubutsu Ryoho.  Medicinal Treatment.  (Tokyo, Japan)  V.1-14,
   1968-81.  Suspended.  Volume(issue)/page/year: 10,1585,1977

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1300 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 20,87,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED

TYPE OF TEST            :

其他信息

MOL 文件:2152-44-5.mol
MSDS 信息:1,4-Pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate(2152-44-5).msds
用途一:激素药，抗炎。
Sigma Aldrich:2152-44-5(sigmaaldrich)