DAPT (2S)-N-[N-(3,5-二氟苯乙酰基)-L-丙氨酰]-2-苯基甘氨酸叔丁酯
CAS 208255-80-5 MFCD04974585
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D-DIF, Eli Lilly, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, R to Z, gamma Secretase
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, D-DIF, Eli Lilly, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, R to Z, gamma Secretase, 生化试剂, 生物活性小分子, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
- Micchelli, C.A., et al., γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila . FASEB J. 17 , 79-81, (2003) 摘要
- Teachey DT, et al., Targeting Notch signaling in autoimmune and lymphoproliferative disease Blood 111 , 705-714, (2008) 摘要
- Kanungo J, et al., The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins J. Neurochem. 106 , 2236-2248, (2008) 摘要
- Zhang H, et al., The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway Dig. Dis. Sci. 53 , 2195-2203, (2008) 摘要
- Sato T, et. al., A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc. Natl. Acad. Sci. U. S. A. , 1421-6, (2009) 摘要
- Trombly, D.J., et al., Suppression Of Notch Signaling In The Neonatal Mouse Ovary Decreases Primordial Follicle Formation. Endocrinology 150 , 1014-24, (2009) 摘要
- Zhang, C.P., et al., Notch Signaling Is Involved In Ovarian Follicle Development By Regulating Granulosa Cell Proliferation. Endocrinology 152 , 2437-47, (2011) 摘要
- Micchelli, C.A., et al., γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila . FASEB J. 17 , 79-81, (2003) 摘要
- Lammich, S., et al., Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J. Biol. Chem. 277 , 44754-44759, (2002) 摘要
- Dovey, H.F., et al., Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. J. Neurochem. 76 , 173-181, (2001) 摘要
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。