Ro 61-8048 3,4-二甲氧基-N-(4-(3-硝基苯基)噻唑-2-基)苯磺酰胺
CAS 199666-03-0 MFCD11040807
化学结构图
SMILES: COc1ccc(S(=O)(=O)Nc2nc(-c3cccc([N+](=O)[O-])c3)cs2)cc1OC
化学属性
| Mol. Formula | C17H15N3O6S2 |
|---|---|
| Mol. Weight | 421.45 |
别名和识别编码
| Chemical Name | Ro 61-8048 |
|---|---|
| Synonym | 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide 3,4-Dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide Ro-61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide Ro 61-8048 Ro-61-8048 Ro-61-8048 sulfonamide |
| MDL Number | MFCD11040807 |
| CAS Number | 199666-03-0 |
| PubChem Substance ID | 5282337 |
| Chemical Name Translation | 3,4-二甲氧基-N-(4-(3-硝基苯基)噻唑-2-基)苯磺酰胺 |
| InChI | InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) |
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分类
- {SNA} Alzheimer's Disease, Assays/Reagents for Alzheimer's Disease Research, Bioactive Small Molecule Alphabetical Index, Neurobiology, Neuroscience, Products for Neurodegenerative Disease Research, R, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Alzheimer′s Disease, Assays/Reagents for Alzheimer′s Disease Research, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Products for Neurodegenerative Disease Research, R
相关文献及参考
- Rodgers J, Stone TW, Barrett MP, Bradley B, Kennedy PG., Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain pt 5 , 1259-67, (2009)
- Hamann M, Sander SE, Richter A., Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur. J. Pharmacol. 1-3 , 156-9, (2008)
- Cozzi A, Carpenedo R, Moroni F., Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J. Cereb. Blood Flow Metab. 7 , 771-7, (1999)
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P305+P351+P338
- P330 Rinse mouth. 漱口
- P337+P313
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
- R36 Irritating to eyes 刺激眼睛
