Vinflunine Ditartrate
CAS 194468-36-5 MFCD94468365
化学结构图
SMILES: CC(F)(F)[C@H]1CN2C[C@@H](C[C@@](C3NC4C=CC=CC=4C=3C2)(C2=CC3=C(C=C2OC)N(C)[C@H]2[C@](O)([C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]32[C@H]45)C(=O)OC)C(=O)OC)C1
化学属性
| Mol. Weight | 1117 |
|---|---|
| Mol. Formula | C53H66F2N4O20 |
别名和识别编码
| CAS Number | 194468-36-5 |
|---|---|
| Chemical Name | Vinflunine Ditartrate |
| Synonym | ######## |
| Chemical Name Translation | |
| MDL Number | MFCD00938122 |
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资金保障
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分类
- Aromatics
- Heterocycles
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Vinflunine is a semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity. Vinflunine is a derivative of Vinorelbine. Vinflunine is used as an antineoplastic.
相关文献及参考
- [2]. Kruczynski A, et, al. Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer. 2006 Nov;42(16):2821-32.
- Bennouna, J. et al.: Ann. Oncol., 14, 630 (2003),
- Fabre, C., et al.: Biochem. Pharmacol., 64, 733 (2002),
- Kruczynski, A., et al.: Crit. Rev. Oncol. Hematol., 40, 159 (2001),
- [1]. Bennouna J, et, al. Vinflunine: a new microtubule inhibitor agent. Clin Cancer Res. 2008 Mar 15;14(6):1625-32.
- [1]. Bennouna J, et, al. Vinflunine: a new microtubule inhibitor agent. Clin Cancer Res. 2008 Mar 15;14(6):1625-32.
- [2]. Kruczynski A, et, al. Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer. 2006 Nov;42(16):2821-32.
