CAS 1918-16-7 MFCD00078731-Propachlor 毒草胺 TAO{mole}

Propachlor 毒草胺

CAS 1918-16-7 MFCD00078731

化学结构图

SMILES: CC(C)N(C(=O)CCl)c1ccccc1

化学属性

Mol. Formula	C11H14ClNO
Mol. Weight	212
Melting Point	67-76°C
Density	0.791
Flash Point	100 °C
Solubility	微溶于水，易溶于苯、丙酮、乙醇、甲苯、四氯化碳。

别名和识别编码

Chemical Name	Propachlor
Synonym	2'-CHLORO-N-ISOPROPYL ACETANILIDE 2-CHLORO-N-ISOPROPYL-N-PHENYLACETAMIDE 2-Chlor-N-isopropyl-acetanilid 2-Chloro-N-(1-methylethyl)-N-phenylacetamide 2-Chloro-N-isopropyl-N-phenylacetamide 2-Chloro-N-isopropylacetanilide 2-chloro-N-(1-methylethyl)-N-phenylacetamide 2-chloro-N-(1-methylethyl)-N-phenylethanamide 2-chloro-N-isopropylacetamide 2-chloro-N-isopropylacetanilide 2-chloro-n-(1-methylethyl)-n-phenyl-acetamid 2-chloro-n-isopropyl-acetanilid 2-氯-N-(1-甲基乙基)-N-苯 2-氯-N-异丙基乙酰苯胺 A-CHLORO-N-ISO-PROPYLACETANILIDE ALBRASS ATLAS PROPACHLOR Acetamide, 2-chloro-N-(1-methylethyl)-N-phenyl- Acetanilide, 2-chloro-N-isopropyl- Acilid Bexton Bexton 4L CP 31393 {P
MDL Number	MFCD00078731
CAS Number	1918-16-7
PubChem Substance ID	4931
Beilstein Registry Number	2103903
EC Number	217-638-2
Chemical Name Translation	毒草胺
Merck Number	13,7885
Wiswesser Line Notation	G1VNR&Y1&1
InChI	InChI=1S/C11H14ClNO/c1-9(2)13(11(14)8-12)10-6-4-3-5-7-10/h3-7,9H,8H2,1-2H3

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产品应用

选择性芽前除草剂。用于水稻、棉花、玉米、花生、甘蔗、豌豆、蚕豆、油菜田及苗圃中，防除一年生禾本科杂草和某些阔叶草，如稗草、马唐、狗尾草、野燕麦、苋、藜、马齿苋、牛毛草等

安全信息

RTECSAE1575000

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P317
P302+P352
P305+P351+P338
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P333+P313
P333+P317
P337+P313
P337+P317
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn;N Xn,N Xn;N,N,Xn

Safety Statements

S24 Avoid contact with skin 避免皮肤接触；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S37 Wear suitable gloves 戴适当手套；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R36 Irritating to eyes 刺激眼睛
R50/53
R22 Harmful if swallowed 吞咽有害
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

UN Number 2811 UN 2811

Storage condition 室温储存 0-6°C

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 306 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 41(7),38,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 710 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson
   Publications, 1976/77 revision  Volume(issue)/page/year: 2,63,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
D

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 672 mg/kg/16W (Intermittent)
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 18,35,1979

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 672 mg/kg/16W (Intermittent)
REFERENCE :
   EKMMA8 Eksperimentalna Meditsina i Morfologiya.  (Hemus, Blvd. Russki 6,
   Sofia, Bulgaria) V.1-    1962-  Volume(issue)/page/year: 18,35,1979

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 14(6),38,1980

其他信息

下游产品:丁二酸 --> 烷氧基乙醇酰胺琥珀酸单酯钠盐 --> 野麦畏 --> 羊毛防缩整理剂 W-G3 --> 表面活性剂 NPES
注意事项:若溅入眼睛和皮肤，立即用清水冲洗，出现中毒症状送医院对症状治疗
上游原料:氯乙酰氯 --> 2-氯丙烷 --> N-异丙基苯胺
灭火剂:干粉、泡沫、砂土
Sigma Aldrich:1918-16-7(sigmaaldrich)
急救治疗:出现中毒症状送医院对症状治疗。
可燃性危险特性:燃烧产生有毒氮氧化物和氯化物气体
方法二:苯胺与2-氯丙烷在130-140℃，约1MPa压力下反应4h，降温至95℃，泄压后缓慢滴加氯乙酰氯，于100℃反应3h，即制得毒草胺。原料消耗定额：苯胺530kg/t、丙烯410kg/t、盐酸520kg/t、氯乙酰氯740kg/t、氯化钙200kg/t。
MSDS 信息:毒草安(1918-16-7).msds
储运特性:库房通风低温干燥; 与食品原料分开储运
MOL 文件:1918-16-7.mol
类别:农药
方法一:苯胺与2-氯丙烷于130～140℃，1MPa压力下反应4h，制得N-异丙基苯胺；降温至95℃，泄压后缓慢滴加氯乙酰氯，于100℃反应3h，制得毒草胺。
外观性质:淡黄褐色固体。
毒性:65%可湿性粉剂对大鼠急性经口LD 50 为1200mg/kg；10.4%水悬液对家兔急性经皮LD 50 380mg/kg。对眼睛有刺激性。鲶鱼LC 50 为1.3mg/L。
用途一:属选择性芽前除草剂
用途三:选择性芽前除草剂。用于水稻、棉花、玉米、花生、甘蔗、豌豆、蚕豆、油菜田及苗圃中，防除一年生禾本科杂草和某些阔叶草，如稗草、马唐、狗尾草、野燕麦、苋、藜、马齿苋、牛毛草等。
急性毒性:口服- 大鼠 LD50: 710 毫克/ 公斤; 口服- 小鼠 LD50: 290 毫克/ 公斤
毒性分级:高毒
杀虫剂单一组分标准液
用途二:酰胺类选择性芽前除草剂，用于水稻、棉花、玉米、花生、甘蔗、油菜、豆类作物，防除一年生禾本科杂草和某些阔叶杂草，如稗草、马唐、狗尾草、野燕麦、苋、藜、马齿苋、牛毛草等。应用剂量35～50g/100m 2 。在此剂量下，药剂在土壤中持效期4～6周。
110℃时蒸气为4×10-3kPa。20℃水中溶解为700mg/L，丙酮30.9%，苯50%，四氯化碳14.8%，乙醇29.0%，甲苯25.5%，常温下稳定，在酸、碱中受热易分解