6-Chloro-N2-Ethyl-N4-Isopropyl-1,3,5-Triazine-2,4-Diamine 6-氯-N2-乙基-N4-异丙基-1,3,5-三嗪-2,4-二胺
CAS 1912-24-9 MFCD00041810
化学结构图
SMILES: CCNc1nc(Cl)nc(NC(C)C)n1
化学属性
| Mol. Formula | C8H14ClN5 |
|---|---|
| Mol. Weight | 216 |
| Appearance | solid |
| Flash Point | 11 °C |
| Melting Point | 175 |
| Density | 1.187 |
| Boiling Point | 200°C |
| Solubility | Slightly soluble. 0.007 g/100 mL |
别名和识别编码
| Chemical Name | 6-Chloro-N2-Ethyl-N4-Isopropyl-1,3,5-Triazine-2,4-Diamine |
|---|---|
| Synonym | 2-CHLORO-4-ETHYLAMINO-6-ISOPROPYL-AMINO-S-TRIAZINE 2-CHLORO-4-ETHYLAMINO-6-ISOPROPYLAMINO-SYM-TRIAZINE 2-Chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine 2-氯-4-乙胺基-6-异丙胺基-均三氮苯 5-三嗪-2 6-氯-N-乙基-N'-(1-甲基乙基)-1 6-氯-N-乙基-N’-(1-甲基乙基)-1,3,5-三嗪-2,4-二胺 6-氯-N2-乙基-N4-异丙基-1,3,5-三嗪-2,4 -二胺; 2- 6-氯-N2-乙基-N4-异丙基三嗪二胺 AATREX ATRAZIN ATRAZINE Aatrex 4L G 30027 GESAPRIM(R) PRIMAGRAM {} {} {} {} { {} {} {} {} {ALD} 盖萨林。2-氯-4-乙氨基-6-异丙氨基-1,3,5-三嗪,6-氯-N-乙基-N' 莠去尽 阿特拉津 阿特拉津 溶液 阿特拉津;莠去津;盖萨林;2-氯-4-乙氨基-6-异丙氨基-1 |
| MDL Number | MFCD00041810 |
| PubChem Substance ID | 87563076 |
| Beilstein Registry Number | 612020 |
| CAS Number | 1912-24-9 |
| EC Number | 217-617-8 |
| Chemical Name Translation | 6-氯-N2-乙基-N4-异丙基-1,3,5-三嗪-2,4-二胺 |
| Reaxys-RN | 612020 |
| Merck Number | 871 |
| Wiswesser Line Notation | T6N CN ENJ BMY1&1 DM2 FG |
| InChI | InChI=1S/C8H14ClN5/c1-4-10-7-12-6(9)13-8(14-7)11-5(2)3/h5H,4H2,1-3H3,(H2,10,11,12,13,14) |
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分类
- {SNA} 2000/60/EC, A, A-B, AN-AZ, AR to AZ, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, Herbicides, Method and Regulation Specific, Pesticides & Metabolites, Standards for SupelMIP SPE, Triazines
- Analytical Standards, Analytical/Chromatography, CRM for chromatography, Certified Reference Materials (CRMs), Organic CRMs TraceCERT, Pesticides
- {SNA
产品应用
- 用于环境监测及分析测试中的质量保证和质量控制，也可用于仪器校准、方法验证和技术仲裁。
相关文献及参考
- Merck 14 ,871
安全信息
GHS Symbol
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P312+P330
- P302+P350
- P302+P352+P333+P313+P362+P364
- P304+P312
- P305+P351+P338+P337+P313
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P337+P313
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H370 Causes damage to organs 导致器官损伤
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H301+H311+H331
- H331 Toxic if inhaled 吸入中毒
- H301 Toxic if swallowed 吞食有毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H302 Harmful if swallowed 吞食有害
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S7 Keep container tightly closed 保存在严格密闭容器中；
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R48/22
- R50/53
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 33775 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 37,533,1990TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9000 mg/kg/78W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 672 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,299,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 48,A192,1979
TYPE OF TEST : LC50
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSUR
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(6),81,1979
TYPE OF TEST : DNA damage TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 100mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 344,41,1995
TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 556 umol/L REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025
TYPE OF TEST : Cytogenetic analysis ROUT
TYPE OF TEST : DNA damage ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 875 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 209,145,1988
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Schizosaccharomyces pombe DOSE/DURATION : 6 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 74,77,1980
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 5 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,291,1992
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Fibroblast DOSE/DURATION : 3 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 74,77,1980
{hTYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 975 mg/kg SEX/DURATION : female 7-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 24,307,1988
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 418 mg/kg SEX/DURATION : female 6-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-160
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE
TYPE OF TEST
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 720 mg/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - behavioral REFERENCE : APHHDU Acta Physiologica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) V.61- 1983- Volume(issue)/page/year: 83,79,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE
其他信息
- {Chemicalbo
- 急性毒性:口服- 大鼠 LD50: 672 毫克/公斤; 口服- 小鼠 LD50: 850 毫克/ 公斤
- 用途五:阿特拉津是内吸选择性苗前、苗后除草剂。以根吸收为主，茎叶吸收很少，迅速传导到植物分生组织及叶部，干扰光合作用，使杂草致死。在玉米等抗性作物体内，被玉米酮酶分解生成无毒物质，因而对作物安全。阿特拉津的水溶性大，在土壤中移动性大于西玛津，易被雨水淋洗至较深层，致使对某些深根性杂草有抑制作用，在土壤中可被微生物分解，残效期视用药剂量、土壤质地等因素影响，可长达半年左右。适用于玉米、高粱、林地、草地、甘蔗等防除一年生和二年生阔叶杂草和单子叶杂草。
- 方法二:三聚氯氰分两步依次和乙胺及异丙胺在碱性介质中反应，取代两个氯原子，生成阿特拉津原药。原料消耗定额：三聚氯氰950kg/t、异丙胺380kg/t、一乙胺250kg/t。
- 类别:农药
- 方法一:三聚氯氰的制备 三聚氯氰是合成均三氮苯类除草剂的重要中间体。它的合成包括氯化和聚合二步反应，反应式如下。 HCN+Cl2→CNCl+HCl 3CNCl[催化剂]→（CNCl)3 美国杜邦公司三聚氯氰的生产工艺如下：氯气和氢氰酸按一定的配比（氯过量）在反应塔下半部进入，塔底引入低压蒸汽，塔顶按规定进入低温水，氯气与氢氰酸在塔内生成氯氰及氯化氢，从塔项得氯氰，由塔底连续排出稀盐酸，含量约4%，送往厂废水站处理。塔顶氯氰与过量氯气经氯化钙、分子筛干燥后（含水<;10mg/L)送往聚合反应器，反应器为立式固定床，催化剂可能是活性炭（结构、催化剂、反应条件属专利），寿命一般3个月，但按生产规定每月换1次，废催化剂送焚烧炉烧却，据称调换催化剂方法很方便。聚合后所得之三聚氯氰送往下步洗涤塔，以溶剂（可能为重质芳烃，要求挥发性小）洗涤，然后贮存于贮槽内供合成均三氮苯除草剂用。吸收后尾气根据分析排空一部分，大部分循环到前步氯氰反应塔，排空之尾气去尾气洗涤塔以碱液及次氯酸钠洗涤处理。氯化反应塔为φ1m×20m高镍钢反应器，三聚反应器为φ2m×6m高镍钢反应器，尾气处理塔为φ2m×20m填料塔。 莠去津的合成 以水-氯苯为溶剂，将三聚氯氰与溶剂混合后，降温至15℃，滴加计量的乙胺，温度自行升高，加入50%量的液碱，于15～20℃反应30min；然后滴加计量的异丙胺和其余的液碱，于30～40℃反应2h。水气蒸馏蒸出氯苯和水，经分离、干燥回收氯苯，釜内科料经降温、离心分离、水洗后，进行干燥，即为原料。 CA110：212860报道了莠去津原药生产方法如下：在表面活性剂存在下，三聚氯氰（C3N3Cl3)与乙胺、异丙胺和氢氧化钠在水解质中或含碱金属氯化物的水溶液中反应，具体操作是：30g三聚氯氰和250mL水的混合物在5℃与0.1mL Slovanik T 610(环氧乙烷/环氧丙烷共聚物）反应，然后与50mL20.0%异丙胺反应，30min后与55mL 10%氢氧化钠水溶液反应，反应温度均为5～10℃，50min混合物与21.5mL39%乙胺水溶液反应，40余分钟后与50mL 10.1%氢氧化钠水溶液反应。50min后，生成物经过滤、洗涤、干燥，得产品33.1g。莠去津97.1%，西玛津1.6%，扑灭津0.9%。
- 毒性分级:中毒
- 用
- 上游原料:氢氧化钠 --> 次氯酸钠 --> 氯苯 --> 三聚氯氰 --> 异丙胺 --> 氢氰酸 --> 氮苯 --> 填料塔
- 用途四:均三嗪类、选择性内吸传导性，苗前、苗后除草剂。用于玉米、高粱、甘蔗、茶树及果园林地防除一年生禾本科杂草和阔叶杂草。对由根茎或根芽繁殖的多年生杂草有抑制作用。如用于玉米地除草，东北地区37.5～60g/100m 2 ，河北、山东地区15～30g/100m 2 ；用于高粱地除草30～53g/100m 2 ；用于苹果、梨园除草，60～75g/100m 2 ；用于茶园除草，23～37.5g/100m 2 使用时药量根据土质有机质含量，杂草种类和密度而定。豆类对药剂敏感，易产生药害。
- 杀虫剂单一组分标准液
- 用途六:阿特拉津是内吸选择性苗前、苗
- 储运特性:库房通风低温干燥; 与食品原料分开储运
- MOL 文件:1912-24-9.mol
- 刺激数据:皮肤- 兔子 38 毫克 轻度; 眼睛- 兔子 6.32 毫克 重度
