(R)-3-((1-Methylpyrrolidin-2-Yl)Methyl)-5-(2-(Phenylsulfonyl)Ethyl)-1H-Indole Hydrobromide (R)-3-((1-甲基-2-吡咯烷基)甲基)-5-(2-(苯磺酰)乙基)-1H-吲哚氢溴酸盐
CAS 177834-92-3 MFCD08141806
化学结构图
SMILES: Br.CN1CCC[C@@H]1CC1=CNC2C=CC(CCS(=O)(=O)C3C=CC=CC=3)=CC1=2
化学属性
| Mol. Formula | C22H27BrN2O2S |
|---|---|
| Mol. Weight | 463 |
| Boiling Point | 633.9 |
| Melting Point | 169-171 |
别名和识别编码
| Chemical Name | (R)-3-((1-Methylpyrrolidin-2-Yl)Methyl)-5-(2-(Phenylsulfonyl)Ethyl)-1H-Indole Hydrobromide |
|---|---|
| Synonym | Eletriptan hydrobromide |
| MDL Number | N/A |
| Chemical Name Translation | (R)-3-((1-甲基-2-吡咯烷基)甲基)-5-(2-(苯磺酰)乙基)-1H-吲哚氢溴酸盐 |
| CAS Number | 177834-92-3 |
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分类
- {SNA} Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, E, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Pfizer Compounds, Proteins and Derivatives, Serotonergics, Serotonergics - Agonists
相关文献及参考
- [2]. MaassenVanDenBrink A, et al. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels. Neurology, 2000, 55(10), 1524-1530.
- [3]. Gupta P, et al. The in vivo pharmacological profile of eletriptan (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur J Pharmacol, 2000, 398(1), 73-81.
- [4]. Hoskin KL, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res, 2004, 998(1), 91-99.
- [1]. Napier C, et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol, 1999, 368(2-3), 259-2
- [1]. Napier C, et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol, 1999, 368(2-3), 259-268.
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
GHS Symbol
- P305+P351+P338
- H319 Causes serious eye irritation 严重刺激眼睛
- R36 Irritating to eyes 刺激眼睛
